ACTH-like molecules in gastropod molluscs: A possible role in ancestral immune response and stress

E. Ottaviani, A. Cossarizza, C. Ortolani, D. Monti, C. Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

The presence of immunoreactive ACTH molecules on phagocytic cells from the freshwater snails Planorbarius corneus and Lymnaea stagnalis was shown by cytofluorimetric analysis. The role of ACTH in phagocytosis and in the release of biogenic amines, two biological responses that may be taken as ancestral types of immune response and stress, respectively, has also been evaluated. ACTH markedly increased the phagocytosis of Staphylococcus aureus by P. corneus haemocytes and caused the release of biogenic amines from such cells into the serum. These data, as well as tracing the ancestral physiological role of ACTH, favour the hypothesis that immune and neuroendocrine systems share a common evolutionary origin.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalProceedings of the Royal Society B: Biological Sciences
Volume245
Issue number1314
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Fingerprint

Dive into the research topics of 'ACTH-like molecules in gastropod molluscs: A possible role in ancestral immune response and stress'. Together they form a unique fingerprint.

Cite this