Actigraphic features of bipolar disorder: A systematic review and meta-analysis

Franco De Crescenzo, Alexis Economou, Ann L Sharpley, Aynur Gormez, Digby J Quested

Research output: Contribution to journalArticle

Abstract

Sleep disruptions represent a core feature of bipolar disorders and have been widely studied through the use of actigraphy, which is an objective measure of motor activity and sleep. Finding objective outcomes, which reliably measure sleep in bipolar disorders, is essential in developing better therapies and improving follow-up monitoring strategies. Our aim is to understand the role of actigraphy as an objective measure of sleep in bipolar disorder. We undertook a systematic review and meta-analysis on studies using actigraphy to detect changes in activity and sleep patterns in bipolar patients versus healthy controls. The primary outcome measures were the analyses of 'activity mean' and 'sleep duration'. As secondary outcomes we analysed 'sleep onset latency', 'sleep efficiency', and 'time awake after sleep onset'. Thirteen studies comprising 821 subjects met quality criteria for inclusion. The results show a decrease in activity mean and an altered pattern of sleep in bipolar patients. Further analyses suggest that the results might be generalized to a bipolar condition which underlies manic and depressed episodes as well as euthymic phases. This study highlights the role of actigraphy as an important objective tool for the ambulatory monitoring of sleep and activity in bipolar disorders.

Original languageEnglish
JournalSleep Medicine Reviews
Early online dateMay 27 2016
DOIs
Publication statusPublished - 2016
Externally publishedYes

Fingerprint

Bipolar Disorder
Meta-Analysis
Sleep
Actigraphy
Ambulatory Monitoring
Motor Activity
Outcome Assessment (Health Care)

Keywords

  • Journal Article
  • Review

Cite this

Actigraphic features of bipolar disorder : A systematic review and meta-analysis. / De Crescenzo, Franco; Economou, Alexis; Sharpley, Ann L; Gormez, Aynur; Quested, Digby J.

In: Sleep Medicine Reviews, 2016.

Research output: Contribution to journalArticle

De Crescenzo, Franco ; Economou, Alexis ; Sharpley, Ann L ; Gormez, Aynur ; Quested, Digby J. / Actigraphic features of bipolar disorder : A systematic review and meta-analysis. In: Sleep Medicine Reviews. 2016.
@article{09038c5c729f4c669b781d549e4c2410,
title = "Actigraphic features of bipolar disorder: A systematic review and meta-analysis",
abstract = "Sleep disruptions represent a core feature of bipolar disorders and have been widely studied through the use of actigraphy, which is an objective measure of motor activity and sleep. Finding objective outcomes, which reliably measure sleep in bipolar disorders, is essential in developing better therapies and improving follow-up monitoring strategies. Our aim is to understand the role of actigraphy as an objective measure of sleep in bipolar disorder. We undertook a systematic review and meta-analysis on studies using actigraphy to detect changes in activity and sleep patterns in bipolar patients versus healthy controls. The primary outcome measures were the analyses of 'activity mean' and 'sleep duration'. As secondary outcomes we analysed 'sleep onset latency', 'sleep efficiency', and 'time awake after sleep onset'. Thirteen studies comprising 821 subjects met quality criteria for inclusion. The results show a decrease in activity mean and an altered pattern of sleep in bipolar patients. Further analyses suggest that the results might be generalized to a bipolar condition which underlies manic and depressed episodes as well as euthymic phases. This study highlights the role of actigraphy as an important objective tool for the ambulatory monitoring of sleep and activity in bipolar disorders.",
keywords = "Journal Article, Review",
author = "{De Crescenzo}, Franco and Alexis Economou and Sharpley, {Ann L} and Aynur Gormez and Quested, {Digby J}",
note = "Copyright {\circledC} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
doi = "10.1016/j.smrv.2016.05.003",
language = "English",
journal = "Sleep Medicine Reviews",
issn = "1087-0792",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Actigraphic features of bipolar disorder

T2 - A systematic review and meta-analysis

AU - De Crescenzo, Franco

AU - Economou, Alexis

AU - Sharpley, Ann L

AU - Gormez, Aynur

AU - Quested, Digby J

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016

Y1 - 2016

N2 - Sleep disruptions represent a core feature of bipolar disorders and have been widely studied through the use of actigraphy, which is an objective measure of motor activity and sleep. Finding objective outcomes, which reliably measure sleep in bipolar disorders, is essential in developing better therapies and improving follow-up monitoring strategies. Our aim is to understand the role of actigraphy as an objective measure of sleep in bipolar disorder. We undertook a systematic review and meta-analysis on studies using actigraphy to detect changes in activity and sleep patterns in bipolar patients versus healthy controls. The primary outcome measures were the analyses of 'activity mean' and 'sleep duration'. As secondary outcomes we analysed 'sleep onset latency', 'sleep efficiency', and 'time awake after sleep onset'. Thirteen studies comprising 821 subjects met quality criteria for inclusion. The results show a decrease in activity mean and an altered pattern of sleep in bipolar patients. Further analyses suggest that the results might be generalized to a bipolar condition which underlies manic and depressed episodes as well as euthymic phases. This study highlights the role of actigraphy as an important objective tool for the ambulatory monitoring of sleep and activity in bipolar disorders.

AB - Sleep disruptions represent a core feature of bipolar disorders and have been widely studied through the use of actigraphy, which is an objective measure of motor activity and sleep. Finding objective outcomes, which reliably measure sleep in bipolar disorders, is essential in developing better therapies and improving follow-up monitoring strategies. Our aim is to understand the role of actigraphy as an objective measure of sleep in bipolar disorder. We undertook a systematic review and meta-analysis on studies using actigraphy to detect changes in activity and sleep patterns in bipolar patients versus healthy controls. The primary outcome measures were the analyses of 'activity mean' and 'sleep duration'. As secondary outcomes we analysed 'sleep onset latency', 'sleep efficiency', and 'time awake after sleep onset'. Thirteen studies comprising 821 subjects met quality criteria for inclusion. The results show a decrease in activity mean and an altered pattern of sleep in bipolar patients. Further analyses suggest that the results might be generalized to a bipolar condition which underlies manic and depressed episodes as well as euthymic phases. This study highlights the role of actigraphy as an important objective tool for the ambulatory monitoring of sleep and activity in bipolar disorders.

KW - Journal Article

KW - Review

U2 - 10.1016/j.smrv.2016.05.003

DO - 10.1016/j.smrv.2016.05.003

M3 - Article

C2 - 28185811

JO - Sleep Medicine Reviews

JF - Sleep Medicine Reviews

SN - 1087-0792

ER -