Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression

Francesco Benedetti; Sara Dallaspezia; Mara Cigala Fulgosi; Cristina Lorenzi; Alessandro Serretti; Barbara Barbini; Cristina Colombo; Enrico Smeraldi

doi:10.1002/ajmg.b.30475

Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression

Francesco Benedetti, Sara Dallaspezia, Mara Cigala Fulgosi, Cristina Lorenzi, Alessandro Serretti, Barbara Barbini, Cristina Colombo, Enrico Smeraldi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Depressive insomnia and diurnal fluctuations of mood and activity are core clinical features of mood disorders. Here we studied the effect of CLOCK 3111 T/C SNP (rs1801260) on the actimetric recorded diurnal activity and nocturnal sleep of 39 bipolar depressed inpatients. Compared to T/T homozygotes, carriers of the C allele had a similar degree of severity of depression, but showed higher activity levels in the evening, a delayed sleep onset (mean 79 min later), and a reduced amount of sleep during the night (mean 75 min less). Ongoing lithium treatment significantly interacted with rs1801260 by enhancing activity levels in the evening and reducing the differences among genotype groups. Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders.

Original language	English
Pages (from-to)	631-635
Number of pages	5
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	144
Issue number	5
DOIs	https://doi.org/10.1002/ajmg.b.30475
Publication status	Published - Jul 5 2007

Keywords

Actigraphy
Bipolar disorder
CLOCK gene
Insomnia
Lithium
Polymorphism

ASJC Scopus subject areas

Genetics(clinical)
Neuropsychology and Physiological Psychology
Neuroscience(all)

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10.1002/ajmg.b.30475

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Benedetti, F., Dallaspezia, S., Fulgosi, M. C., Lorenzi, C., Serretti, A., Barbini, B., Colombo, C., & Smeraldi, E. (2007). Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression. American Journal of Medical Genetics - Neuropsychiatric Genetics, 144(5), 631-635. https://doi.org/10.1002/ajmg.b.30475

Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression. / Benedetti, Francesco; Dallaspezia, Sara; Fulgosi, Mara Cigala et al.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 144, No. 5, 05.07.2007, p. 631-635.

Research output: Contribution to journal › Article › peer-review

Benedetti, F, Dallaspezia, S, Fulgosi, MC, Lorenzi, C, Serretti, A, Barbini, B, Colombo, C & Smeraldi, E 2007, 'Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 144, no. 5, pp. 631-635. https://doi.org/10.1002/ajmg.b.30475

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abstract = "Depressive insomnia and diurnal fluctuations of mood and activity are core clinical features of mood disorders. Here we studied the effect of CLOCK 3111 T/C SNP (rs1801260) on the actimetric recorded diurnal activity and nocturnal sleep of 39 bipolar depressed inpatients. Compared to T/T homozygotes, carriers of the C allele had a similar degree of severity of depression, but showed higher activity levels in the evening, a delayed sleep onset (mean 79 min later), and a reduced amount of sleep during the night (mean 75 min less). Ongoing lithium treatment significantly interacted with rs1801260 by enhancing activity levels in the evening and reducing the differences among genotype groups. Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders.",

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AU - Serretti, Alessandro

AU - Barbini, Barbara

AU - Colombo, Cristina

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Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression

Abstract

Keywords

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