TY - JOUR
T1 - Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression
AU - Benedetti, Francesco
AU - Dallaspezia, Sara
AU - Fulgosi, Mara Cigala
AU - Lorenzi, Cristina
AU - Serretti, Alessandro
AU - Barbini, Barbara
AU - Colombo, Cristina
AU - Smeraldi, Enrico
PY - 2007/7/5
Y1 - 2007/7/5
N2 - Depressive insomnia and diurnal fluctuations of mood and activity are core clinical features of mood disorders. Here we studied the effect of CLOCK 3111 T/C SNP (rs1801260) on the actimetric recorded diurnal activity and nocturnal sleep of 39 bipolar depressed inpatients. Compared to T/T homozygotes, carriers of the C allele had a similar degree of severity of depression, but showed higher activity levels in the evening, a delayed sleep onset (mean 79 min later), and a reduced amount of sleep during the night (mean 75 min less). Ongoing lithium treatment significantly interacted with rs1801260 by enhancing activity levels in the evening and reducing the differences among genotype groups. Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders.
AB - Depressive insomnia and diurnal fluctuations of mood and activity are core clinical features of mood disorders. Here we studied the effect of CLOCK 3111 T/C SNP (rs1801260) on the actimetric recorded diurnal activity and nocturnal sleep of 39 bipolar depressed inpatients. Compared to T/T homozygotes, carriers of the C allele had a similar degree of severity of depression, but showed higher activity levels in the evening, a delayed sleep onset (mean 79 min later), and a reduced amount of sleep during the night (mean 75 min less). Ongoing lithium treatment significantly interacted with rs1801260 by enhancing activity levels in the evening and reducing the differences among genotype groups. Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders.
KW - Actigraphy
KW - Bipolar disorder
KW - CLOCK gene
KW - Insomnia
KW - Lithium
KW - Polymorphism
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U2 - 10.1002/ajmg.b.30475
DO - 10.1002/ajmg.b.30475
M3 - Article
C2 - 17221848
AN - SCOPUS:34447546856
VL - 144
SP - 631
EP - 635
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 5
ER -