Action of ethanol and salsolinol on opiate receptor function

L. Lucchi, A. Bosio, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

Ethanol may act at the enkephalinergic receptor level through condensation products such as salsolinol. This fact has been demonstrated by studying the 'in vitro' salsolinol interaction on enkephalinergic receptor sites labeled by [3H-Met]enkephalin. The modification induced by chronic ethanol and salsolinol on this neuronal system is a reduction of the affinity of the receptor for its ligand. These data suggest that a down regulation process due to the continuous opiate receptor stimulation occurs after ethanol administration.

Original languageEnglish
Pages (from-to)506-510
Number of pages5
JournalBrain Research
Volume232
Issue number2
DOIs
Publication statusPublished - Jan 28 1982

Keywords

  • ethanol
  • opiate receptors
  • salsolinol

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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