Activated adherent large granular lymphocytes/natural killer (LGL/NK) cells change their migratory behaviour

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Abstract

Unstimulated large granular lymphocytes/natural killer (LGL/NK) cells, unlike small T lymphocytes, exhibit prompt locomotion into nitrocellulose filters in response to chemo-attractrants, but, unlike monocytes, are unable to migrate as adherent cells across polycarbonate filters. Upon activation with 4-B-phorbol 12,13-dibutyrate (PDBU), LGL/NK cells become adherent and change their migratory behaviour, having the ability to migrate as adherent cells across polycarbonate filters. PDBU-treated high-density T lymphocytes did not show, under the same conditions, locomotory activity. The change in migratory behaviour following activation may represent an important determinant of the ability of activated LGL/NK cells to adhere to vascular linings and localize in tissues.

Original languageEnglish
Pages (from-to)651-653
Number of pages3
JournalImmunology
Volume65
Issue number4
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology

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