Activated adherent large granular lymphocytes/natural killer (LGL/NK) cells change their migratory behaviour

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Unstimulated large granular lymphocytes/natural killer (LGL/NK) cells, unlike small T lymphocytes, exhibit prompt locomotion into nitrocellulose filters in response to chemo-attractrants, but, unlike monocytes, are unable to migrate as adherent cells across polycarbonate filters. Upon activation with 4-B-phorbol 12,13-dibutyrate (PDBU), LGL/NK cells become adherent and change their migratory behaviour, having the ability to migrate as adherent cells across polycarbonate filters. PDBU-treated high-density T lymphocytes did not show, under the same conditions, locomotory activity. The change in migratory behaviour following activation may represent an important determinant of the ability of activated LGL/NK cells to adhere to vascular linings and localize in tissues.

Original languageEnglish
Pages (from-to)651-653
Number of pages3
JournalImmunology
Volume65
Issue number4
Publication statusPublished - 1988

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polycarbonate
Natural Killer Cells
Phorbol 12,13-Dibutyrate
Lymphocytes
T-Lymphocytes
Collodion
Locomotion
Blood Vessels
Monocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Activated adherent large granular lymphocytes/natural killer (LGL/NK) cells change their migratory behaviour. / Pirelli, A.; Allavena, P.; Mantovani, A.

In: Immunology, Vol. 65, No. 4, 1988, p. 651-653.

Research output: Contribution to journalArticle

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