Activated and 'memory' phenotype of circulating T lymphocytes in intrauterine life

R. Paganelli, M. Cherchi, E. Scala, E. Maggi, M. Carbonari, G. Ferranti, L. Dell'Anna, A. Pachi, M. Fiorilli

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We examined the expression of T cell markers in the peripheral blood of five immunologically normal human fetuses at 18-20 weeks of gestational age. The distribution of T cells expressing CD1, CD3, CD4, CD8, CD56, and the α/β and γ/δ receptors for antigen was comparable to that of newborns and normal adults, except for the absence of γ/δ cells expressing the δTCS-1 epitope. The Vβ repertoire, as evaluated by two-color flow cytometry using mAbs to specific Vβ families, was also comparable to that of adult samples. A significant fraction (8.9 to 16.4%) of fetal CD3+ T cells expressed the α chain of IL-2R (CD25) in the absence of HLA-DR; this suggest that antigenic stimuli trigger, during intrauterine life, an unusual pathway of T cell activation. Consistent with this, 7 to 27% of fetal T cells were found to express the CD45R0 marker of 'memory' cells.

Original languageEnglish
Pages (from-to)486-492
Number of pages7
JournalCellular Immunology
Volume155
Issue number2
DOIs
Publication statusPublished - 1994

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T-Lymphocytes
Phenotype
CD56 Antigens
HLA-DR Antigens
Gestational Age
Epitopes
Flow Cytometry
Fetus
Color

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Paganelli, R., Cherchi, M., Scala, E., Maggi, E., Carbonari, M., Ferranti, G., ... Fiorilli, M. (1994). Activated and 'memory' phenotype of circulating T lymphocytes in intrauterine life. Cellular Immunology, 155(2), 486-492. https://doi.org/10.1006/cimm.1994.1140

Activated and 'memory' phenotype of circulating T lymphocytes in intrauterine life. / Paganelli, R.; Cherchi, M.; Scala, E.; Maggi, E.; Carbonari, M.; Ferranti, G.; Dell'Anna, L.; Pachi, A.; Fiorilli, M.

In: Cellular Immunology, Vol. 155, No. 2, 1994, p. 486-492.

Research output: Contribution to journalArticle

Paganelli, R, Cherchi, M, Scala, E, Maggi, E, Carbonari, M, Ferranti, G, Dell'Anna, L, Pachi, A & Fiorilli, M 1994, 'Activated and 'memory' phenotype of circulating T lymphocytes in intrauterine life', Cellular Immunology, vol. 155, no. 2, pp. 486-492. https://doi.org/10.1006/cimm.1994.1140
Paganelli, R. ; Cherchi, M. ; Scala, E. ; Maggi, E. ; Carbonari, M. ; Ferranti, G. ; Dell'Anna, L. ; Pachi, A. ; Fiorilli, M. / Activated and 'memory' phenotype of circulating T lymphocytes in intrauterine life. In: Cellular Immunology. 1994 ; Vol. 155, No. 2. pp. 486-492.
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