Abstract
In this study we analysed the potential of highly purified polyclonal TcR αβ+, TcR γδ+ and CD3- NK cells, to produce lymphokines in response to mitogenic stimulation. RNA hybridizations were performed to detect with high sensitivity the induction of multiple lymphokine genes. Upon stimulation with lectin and phorbol ester TcR γδ+ lymphocytes expressed the same set of lymphokine genes as the TcR αβ+ lymphocytes, which included IL-2, -3, -4, -5, GM-CSF, TNFα and β, IFNγ. In contrast, a more limited set of lymphocykine genes (GM-CSF, TNFα and β, IFNγ) was induced in activated CD3- NK cells, thus indicating that this subpopulation of cells may display different regulatory functions, with respect to CD3+ T lymphocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 247-252 |
| Number of pages | 6 |
| Journal | Scandinavian Journal of Immunology |
| Volume | 33 |
| Issue number | 3 |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Immunology
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Activated CD3- CD16+ natural killer cells express a subset of the lymphokine genes induced in activated αβ+ and γδ+ T cells. / Biassoni, R.; Ferrini, S.; Prigione, I.; Pelak, V. S.; Sekaly, R. P.; Long, E. O.
In: Scandinavian Journal of Immunology, Vol. 33, No. 3, 1991, p. 247-252.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Activated CD3- CD16+ natural killer cells express a subset of the lymphokine genes induced in activated αβ+ and γδ+ T cells
AU - Biassoni, R.
AU - Ferrini, S.
AU - Prigione, I.
AU - Pelak, V. S.
AU - Sekaly, R. P.
AU - Long, E. O.
PY - 1991
Y1 - 1991
N2 - In this study we analysed the potential of highly purified polyclonal TcR αβ+, TcR γδ+ and CD3- NK cells, to produce lymphokines in response to mitogenic stimulation. RNA hybridizations were performed to detect with high sensitivity the induction of multiple lymphokine genes. Upon stimulation with lectin and phorbol ester TcR γδ+ lymphocytes expressed the same set of lymphokine genes as the TcR αβ+ lymphocytes, which included IL-2, -3, -4, -5, GM-CSF, TNFα and β, IFNγ. In contrast, a more limited set of lymphocykine genes (GM-CSF, TNFα and β, IFNγ) was induced in activated CD3- NK cells, thus indicating that this subpopulation of cells may display different regulatory functions, with respect to CD3+ T lymphocytes.
AB - In this study we analysed the potential of highly purified polyclonal TcR αβ+, TcR γδ+ and CD3- NK cells, to produce lymphokines in response to mitogenic stimulation. RNA hybridizations were performed to detect with high sensitivity the induction of multiple lymphokine genes. Upon stimulation with lectin and phorbol ester TcR γδ+ lymphocytes expressed the same set of lymphokine genes as the TcR αβ+ lymphocytes, which included IL-2, -3, -4, -5, GM-CSF, TNFα and β, IFNγ. In contrast, a more limited set of lymphocykine genes (GM-CSF, TNFα and β, IFNγ) was induced in activated CD3- NK cells, thus indicating that this subpopulation of cells may display different regulatory functions, with respect to CD3+ T lymphocytes.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025972143&partnerID=8YFLogxK
M3 - Article
C2 - 1707180
AN - SCOPUS:0025972143
VL - 33
SP - 247
EP - 252
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
SN - 0300-9475
IS - 3
ER -