Activated lymphocytes in glioblastoma

Significance for anti-tumoral immunity

L. Lorusso, R. Nano, E. Capelli, K. Marinu-Aktipi, E. Benericetti, G. Giardini, M. Ceroni

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Interaction between immune cells and tumoral cells of a case of glioblastoma was studied. Tissue fragments obtained during neurosurgery from different areas of the tumor were examined before and after rIL-2 treatment in vitro. The same morphofunctional type of cells usually activated by rIL-2, which show antitumoral reactivity, was observed both in the glioblastoma imprints and in tumoral fragments cultured with rIL-2. This cytokine stimulated the proliferation of tumor infiltrating lymphocytes in vitro. This preliminary study shows that IL-2 potentiates the differentiation of HMS cells in peripheral blood which probably pass through the blood brain barrier and infiltrate the tumor.

Original languageEnglish
Pages (from-to)198-205
Number of pages8
JournalActa Neurologica
Volume49
Issue number4
Publication statusPublished - 1994

Fingerprint

Glioblastoma
Immunity
Lymphocytes
Tumor-Infiltrating Lymphocytes
Neurosurgery
Blood-Brain Barrier
Interleukin-2
Cell Differentiation
Neoplasms
Cytokines
In Vitro Techniques

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lorusso, L., Nano, R., Capelli, E., Marinu-Aktipi, K., Benericetti, E., Giardini, G., & Ceroni, M. (1994). Activated lymphocytes in glioblastoma: Significance for anti-tumoral immunity. Acta Neurologica, 49(4), 198-205.

Activated lymphocytes in glioblastoma : Significance for anti-tumoral immunity. / Lorusso, L.; Nano, R.; Capelli, E.; Marinu-Aktipi, K.; Benericetti, E.; Giardini, G.; Ceroni, M.

In: Acta Neurologica, Vol. 49, No. 4, 1994, p. 198-205.

Research output: Contribution to journalArticle

Lorusso, L, Nano, R, Capelli, E, Marinu-Aktipi, K, Benericetti, E, Giardini, G & Ceroni, M 1994, 'Activated lymphocytes in glioblastoma: Significance for anti-tumoral immunity', Acta Neurologica, vol. 49, no. 4, pp. 198-205.
Lorusso L, Nano R, Capelli E, Marinu-Aktipi K, Benericetti E, Giardini G et al. Activated lymphocytes in glioblastoma: Significance for anti-tumoral immunity. Acta Neurologica. 1994;49(4):198-205.
Lorusso, L. ; Nano, R. ; Capelli, E. ; Marinu-Aktipi, K. ; Benericetti, E. ; Giardini, G. ; Ceroni, M. / Activated lymphocytes in glioblastoma : Significance for anti-tumoral immunity. In: Acta Neurologica. 1994 ; Vol. 49, No. 4. pp. 198-205.
@article{5594af21439d4751ba8f85455207fa6f,
title = "Activated lymphocytes in glioblastoma: Significance for anti-tumoral immunity",
abstract = "Interaction between immune cells and tumoral cells of a case of glioblastoma was studied. Tissue fragments obtained during neurosurgery from different areas of the tumor were examined before and after rIL-2 treatment in vitro. The same morphofunctional type of cells usually activated by rIL-2, which show antitumoral reactivity, was observed both in the glioblastoma imprints and in tumoral fragments cultured with rIL-2. This cytokine stimulated the proliferation of tumor infiltrating lymphocytes in vitro. This preliminary study shows that IL-2 potentiates the differentiation of HMS cells in peripheral blood which probably pass through the blood brain barrier and infiltrate the tumor.",
author = "L. Lorusso and R. Nano and E. Capelli and K. Marinu-Aktipi and E. Benericetti and G. Giardini and M. Ceroni",
year = "1994",
language = "English",
volume = "49",
pages = "198--205",
journal = "Acta Neurologica",
issn = "0001-6276",
number = "4",

}

TY - JOUR

T1 - Activated lymphocytes in glioblastoma

T2 - Significance for anti-tumoral immunity

AU - Lorusso, L.

AU - Nano, R.

AU - Capelli, E.

AU - Marinu-Aktipi, K.

AU - Benericetti, E.

AU - Giardini, G.

AU - Ceroni, M.

PY - 1994

Y1 - 1994

N2 - Interaction between immune cells and tumoral cells of a case of glioblastoma was studied. Tissue fragments obtained during neurosurgery from different areas of the tumor were examined before and after rIL-2 treatment in vitro. The same morphofunctional type of cells usually activated by rIL-2, which show antitumoral reactivity, was observed both in the glioblastoma imprints and in tumoral fragments cultured with rIL-2. This cytokine stimulated the proliferation of tumor infiltrating lymphocytes in vitro. This preliminary study shows that IL-2 potentiates the differentiation of HMS cells in peripheral blood which probably pass through the blood brain barrier and infiltrate the tumor.

AB - Interaction between immune cells and tumoral cells of a case of glioblastoma was studied. Tissue fragments obtained during neurosurgery from different areas of the tumor were examined before and after rIL-2 treatment in vitro. The same morphofunctional type of cells usually activated by rIL-2, which show antitumoral reactivity, was observed both in the glioblastoma imprints and in tumoral fragments cultured with rIL-2. This cytokine stimulated the proliferation of tumor infiltrating lymphocytes in vitro. This preliminary study shows that IL-2 potentiates the differentiation of HMS cells in peripheral blood which probably pass through the blood brain barrier and infiltrate the tumor.

UR - http://www.scopus.com/inward/record.url?scp=0027943783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027943783&partnerID=8YFLogxK

M3 - Article

VL - 49

SP - 198

EP - 205

JO - Acta Neurologica

JF - Acta Neurologica

SN - 0001-6276

IS - 4

ER -