Activating Killer Immunoglobulin Receptors and HLA-C: a successful combination providing HIV-1 control

Mauro S Malnati, Elisabetta Ugolotti, Maria Cristina Monti, Davide De Battista, Irene Vanni, Domenico Bordo, Francesca Sironi, Patrizia Larghero, Eddi Di Marco, Priscilla Biswas, Guido Poli, Elisa Vicenzi, Agostino Riva, Maciej Tarkowski, Giuseppe Tambussi, Silvia Nozza, Gino Tripodi, Francesco Marras, Andrea De Maria, Angela PistorioRoberto Biassoni

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Abstract

Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia.

Original languageEnglish
Pages (from-to)42470
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - Feb 13 2017

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Keywords

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Cite this

Malnati, M. S., Ugolotti, E., Monti, M. C., Battista, D. D., Vanni, I., Bordo, D., Sironi, F., Larghero, P., Marco, E. D., Biswas, P., Poli, G., Vicenzi, E., Riva, A., Tarkowski, M., Tambussi, G., Nozza, S., Tripodi, G., Marras, F., De Maria, A., ... Biassoni, R. (2017). Activating Killer Immunoglobulin Receptors and HLA-C: a successful combination providing HIV-1 control. Scientific Reports, 7, 42470. https://doi.org/10.1038/srep42470