Activating Killer Immunoglobulin Receptors and HLA-C: A successful combination providing HIV-1 control

MS Malnati, E Ugolotti, MC Monti, Davide De Battista, Irene Vanni, D Bordo, F Sironi, Patrizia Larghero, E Di Marco, P Biswas, G Poli, E Vicenzi, A Riva, M Tarkowski, G Tambussi, S Nozza, G Tripodi, F Marras, A De Maria, A PistorioR Biassoni

Research output: Contribution to journalArticlepeer-review

Abstract

Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia. © The Author(s) 2017.
Original languageEnglish
Article number42470
JournalScientific Reports
Volume7
Issue number25
DOIs
Publication statusPublished - 2017

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