Activating Killer Immunoglobulin Receptors and HLA-C: A successful combination providing HIV-1 control

MS Malnati; E Ugolotti; MC Monti; Davide De Battista; Irene Vanni; D Bordo; F Sironi; Patrizia Larghero; E Di Marco; P Biswas; G Poli; E Vicenzi; A Riva; M Tarkowski; G Tambussi; S Nozza; G Tripodi; F Marras; A De Maria; A Pistorio; R Biassoni

doi:10.1038/srep42470

Activating Killer Immunoglobulin Receptors and HLA-C: A successful combination providing HIV-1 control

MS Malnati, E Ugolotti, MC Monti, Davide De Battista, Irene Vanni, D Bordo, F Sironi, Patrizia Larghero, E Di Marco, P Biswas, G Poli, E Vicenzi, A Riva, M Tarkowski, G Tambussi, S Nozza, G Tripodi, F Marras, A De Maria, A PistorioR Biassoni

Research output: Contribution to journal › Article › peer-review

Abstract

Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia. © The Author(s) 2017.

Original language	English
Article number	42470
Journal	Scientific Reports
Volume	7
Issue number	25
DOIs	https://doi.org/10.1038/srep42470
Publication status	Published - 2017

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Malnati, MS., Ugolotti, E., Monti, MC., De Battista, D., Vanni, I., Bordo, D., Sironi, F., Larghero, P., Di Marco, E., Biswas, P., Poli, G., Vicenzi, E., Riva, A., Tarkowski, M., Tambussi, G., Nozza, S., Tripodi, G., Marras, F., De Maria, A., ... Biassoni, R. (2017). Activating Killer Immunoglobulin Receptors and HLA-C: A successful combination providing HIV-1 control. Scientific Reports, 7(25), [42470]. https://doi.org/10.1038/srep42470

Activating Killer Immunoglobulin Receptors and HLA-C: A successful combination providing HIV-1 control. / Malnati, MS; Ugolotti, E; Monti, MC; De Battista, Davide; Vanni, Irene; Bordo, D; Sironi, F; Larghero, Patrizia; Di Marco, E; Biswas, P; Poli, G ; Vicenzi, E; Riva, A; Tarkowski, M; Tambussi, G ; Nozza, S ; Tripodi, G; Marras, F; De Maria, A ; Pistorio, A ; Biassoni, R.

In: Scientific Reports, Vol. 7, No. 25, 42470, 2017.

Research output: Contribution to journal › Article › peer-review

Malnati, MS, Ugolotti, E, Monti, MC, De Battista, D, Vanni, I, Bordo, D, Sironi, F, Larghero, P, Di Marco, E, Biswas, P, Poli, G , Vicenzi, E, Riva, A, Tarkowski, M, Tambussi, G , Nozza, S , Tripodi, G, Marras, F, De Maria, A , Pistorio, A & Biassoni, R 2017, 'Activating Killer Immunoglobulin Receptors and HLA-C: A successful combination providing HIV-1 control', Scientific Reports, vol. 7, no. 25, 42470. https://doi.org/10.1038/srep42470

Malnati, MS ; Ugolotti, E ; Monti, MC ; De Battista, Davide ; Vanni, Irene ; Bordo, D ; Sironi, F ; Larghero, Patrizia ; Di Marco, E ; Biswas, P ; Poli, G ; Vicenzi, E ; Riva, A ; Tarkowski, M ; Tambussi, G ; Nozza, S ; Tripodi, G ; Marras, F ; De Maria, A ; Pistorio, A ; Biassoni, R. / Activating Killer Immunoglobulin Receptors and HLA-C: A successful combination providing HIV-1 control. In: Scientific Reports. 2017 ; Vol. 7, No. 25.

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abstract = "Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia. {\textcopyright} The Author(s) 2017.",

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AU - Malnati, MS

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AU - Monti, MC

AU - De Battista, Davide

AU - Vanni, Irene

AU - Bordo, D

AU - Sironi, F

AU - Larghero, Patrizia

AU - Di Marco, E

AU - Biswas, P

AU - Poli, G

AU - Vicenzi, E

AU - Riva, A

AU - Tarkowski, M

AU - Tambussi, G

AU - Nozza, S

AU - Tripodi, G

AU - Marras, F

AU - De Maria, A

AU - Pistorio, A

AU - Biassoni, R

PY - 2017

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AB - Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia. © The Author(s) 2017.

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