Abstract
Background. Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. Objective. We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in KSHV-infected and uninfected individuals who have or have not developed cKS. Methods. KIR/HLA genotypes were analyzed by molecular genotyping in 50 KSHV-infected individuals who did or did not have cKS and in 33 age-and sex-matched KSHV seronegative individuals. Results. There was no association of individual KIR, HLA or receptor ligand combinations with KSHV infection. However, activating KIR and KIR/HLA genotypes were significantly more frequent in cKS cases, specifically KIR3DS1, KIR2DS1, and KIR2DS1 with its HLA-C2 ligand. Conclusion. A nonspecific inflammatory response triggered by activation of NK cells upon KIR-HLA interaction could be associated with the pathogenesis of KS.
Original language | English |
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Article number | 9 |
Journal | Infectious Agents and Cancer |
Volume | 7 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- HLA
- Human Herpesvirus 8
- Kaposi's Sarcoma
- KIR
- KSHV
- NK cells
ASJC Scopus subject areas
- Infectious Diseases
- Oncology
- Epidemiology
- Cancer Research