Activating KIR/HLA complexes in classic Kaposi's Sarcoma

Franca R. Guerini; Roberta Mancuso; Simone Agostini; Cristina Agliardi; Milena Zanzottera; Ambra Hernis; Athanasia Tourlaki; Maria G. Calvo; Monica Bellinvia; Lucia Brambilla; Mario Clerici

doi:10.1186/1750-9378-7-922469025

Activating KIR/HLA complexes in classic Kaposi's Sarcoma

Franca R. Guerini, Roberta Mancuso, Simone Agostini, Cristina Agliardi, Milena Zanzottera, Ambra Hernis, Athanasia Tourlaki, Maria G. Calvo, Monica Bellinvia, Lucia Brambilla, Mario Clerici

Research output: Contribution to journal › Article › peer-review

Abstract

Background. Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. Objective. We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in KSHV-infected and uninfected individuals who have or have not developed cKS. Methods. KIR/HLA genotypes were analyzed by molecular genotyping in 50 KSHV-infected individuals who did or did not have cKS and in 33 age-and sex-matched KSHV seronegative individuals. Results. There was no association of individual KIR, HLA or receptor ligand combinations with KSHV infection. However, activating KIR and KIR/HLA genotypes were significantly more frequent in cKS cases, specifically KIR3DS1, KIR2DS1, and KIR2DS1 with its HLA-C2 ligand. Conclusion. A nonspecific inflammatory response triggered by activation of NK cells upon KIR-HLA interaction could be associated with the pathogenesis of KS.

Original language	English
Article number	9
Journal	Infectious Agents and Cancer
Volume	7
Issue number	1
DOIs	https://doi.org/10.1186/1750-9378-7-922469025
Publication status	Published - 2012

Keywords

HLA
Human Herpesvirus 8
Kaposi's Sarcoma
KIR
KSHV
NK cells

ASJC Scopus subject areas

Infectious Diseases
Oncology
Epidemiology
Cancer Research

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Activating KIR/HLA complexes in classic Kaposi's Sarcoma. / Guerini, Franca R.; Mancuso, Roberta ; Agostini, Simone ; Agliardi, Cristina ; Zanzottera, Milena ; Hernis, Ambra; Tourlaki, Athanasia; Calvo, Maria G.; Bellinvia, Monica; Brambilla, Lucia; Clerici, Mario.

In: Infectious Agents and Cancer, Vol. 7, No. 1, 9, 2012.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background. Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. Objective. We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in KSHV-infected and uninfected individuals who have or have not developed cKS. Methods. KIR/HLA genotypes were analyzed by molecular genotyping in 50 KSHV-infected individuals who did or did not have cKS and in 33 age-and sex-matched KSHV seronegative individuals. Results. There was no association of individual KIR, HLA or receptor ligand combinations with KSHV infection. However, activating KIR and KIR/HLA genotypes were significantly more frequent in cKS cases, specifically KIR3DS1, KIR2DS1, and KIR2DS1 with its HLA-C2 ligand. Conclusion. A nonspecific inflammatory response triggered by activation of NK cells upon KIR-HLA interaction could be associated with the pathogenesis of KS.",

keywords = "HLA, Human Herpesvirus 8, Kaposi's Sarcoma, KIR, KSHV, NK cells",

author = "Guerini, {Franca R.} and Roberta Mancuso and Simone Agostini and Cristina Agliardi and Milena Zanzottera and Ambra Hernis and Athanasia Tourlaki and Calvo, {Maria G.} and Monica Bellinvia and Lucia Brambilla and Mario Clerici",

year = "2012",

doi = "10.1186/1750-9378-7-922469025",

language = "English",

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journal = "Infectious Agents and Cancer",

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AU - Guerini, Franca R.

AU - Mancuso, Roberta

AU - Agostini, Simone

AU - Agliardi, Cristina

AU - Zanzottera, Milena

AU - Hernis, Ambra

AU - Tourlaki, Athanasia

AU - Calvo, Maria G.

AU - Bellinvia, Monica

AU - Brambilla, Lucia

AU - Clerici, Mario

PY - 2012

Y1 - 2012

N2 - Background. Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. Objective. We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in KSHV-infected and uninfected individuals who have or have not developed cKS. Methods. KIR/HLA genotypes were analyzed by molecular genotyping in 50 KSHV-infected individuals who did or did not have cKS and in 33 age-and sex-matched KSHV seronegative individuals. Results. There was no association of individual KIR, HLA or receptor ligand combinations with KSHV infection. However, activating KIR and KIR/HLA genotypes were significantly more frequent in cKS cases, specifically KIR3DS1, KIR2DS1, and KIR2DS1 with its HLA-C2 ligand. Conclusion. A nonspecific inflammatory response triggered by activation of NK cells upon KIR-HLA interaction could be associated with the pathogenesis of KS.

AB - Background. Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. Objective. We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in KSHV-infected and uninfected individuals who have or have not developed cKS. Methods. KIR/HLA genotypes were analyzed by molecular genotyping in 50 KSHV-infected individuals who did or did not have cKS and in 33 age-and sex-matched KSHV seronegative individuals. Results. There was no association of individual KIR, HLA or receptor ligand combinations with KSHV infection. However, activating KIR and KIR/HLA genotypes were significantly more frequent in cKS cases, specifically KIR3DS1, KIR2DS1, and KIR2DS1 with its HLA-C2 ligand. Conclusion. A nonspecific inflammatory response triggered by activation of NK cells upon KIR-HLA interaction could be associated with the pathogenesis of KS.

KW - HLA

KW - Human Herpesvirus 8

KW - Kaposi's Sarcoma

KW - KIR

KW - KSHV

KW - NK cells

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Activating KIR/HLA complexes in classic Kaposi's Sarcoma

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Keywords

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