Activating KIR/HLA complexes in classic Kaposi's Sarcoma

Franca R. Guerini, Roberta Mancuso, Simone Agostini, Cristina Agliardi, Milena Zanzottera, Ambra Hernis, Athanasia Tourlaki, Maria G. Calvo, Monica Bellinvia, Lucia Brambilla, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS. Objective. We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in KSHV-infected and uninfected individuals who have or have not developed cKS. Methods. KIR/HLA genotypes were analyzed by molecular genotyping in 50 KSHV-infected individuals who did or did not have cKS and in 33 age-and sex-matched KSHV seronegative individuals. Results. There was no association of individual KIR, HLA or receptor ligand combinations with KSHV infection. However, activating KIR and KIR/HLA genotypes were significantly more frequent in cKS cases, specifically KIR3DS1, KIR2DS1, and KIR2DS1 with its HLA-C2 ligand. Conclusion. A nonspecific inflammatory response triggered by activation of NK cells upon KIR-HLA interaction could be associated with the pathogenesis of KS.

Original languageEnglish
Article number9
JournalInfectious Agents and Cancer
Volume7
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • HLA
  • Human Herpesvirus 8
  • Kaposi's Sarcoma
  • KIR
  • KSHV
  • NK cells

ASJC Scopus subject areas

  • Infectious Diseases
  • Oncology
  • Epidemiology
  • Cancer Research

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