Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters

Cristiana Carbone, Annalisa Adinolfi, Stefano Cinque, Enza Lacivita, Enrico Alleva, Marcello Leopoldo, Walter Adriani

Research output: Contribution to journalArticle

Abstract

Aims: The serotonin 7 receptor (5-HT7R) subtype, coded by Htr7 gene, is broadly expressed in the central nervous system (CNS) with clear involvement in behavioral functions such as learning/memory, regulation of mood, and circadian rhythms. In this study, we assessed effects of 5-HT7R stimulation by administration of its selective agonist, LP-211 (0.25 mg/kg i.p.), in adult Wistar-Han rats. Methods: We used two different explorative-curiosity tests. Drug was administered either before one side-chamber familiarization (CF/V group) or immediately after it, to act on consolidation of familiarization (V/CF group). Results: Exp. 1 for novelty seeking in black/white boxes (BWB), with door opening after 5 minutes in the familiar chamber, showed that (i) time spent in the novel environment (significantly higher than in familiar chamber for controls) is enhanced in V/CF group (potentiated recognition for a “visual” consolidation) and not different in CF/V group; (ii) activity and chamber transitions, made by CF/V rats, are significantly higher than for other groups (interference on recognition for a “spatial” acquisition). Exp. 2 for novelty preference in D- vs L-shaped chambers (D/L), with start from neutral center, gave different results: (i) time spent in the novel environment by CF/V group is significantly higher than other groups (potentiated “cognitive” acquisition); (ii) chamber transitions made by V/CF group are significantly higher than other groups (potentiated “emotional” consolidation). Conclusion: These apparently conflicting results may reflect LP-211 effects on visual vs spatial memory (D/L apparatus has more pronounced hippocampal components than BWB). However, further experiments are needed to analyze more in depth the mechanisms involved.

Original languageEnglish
Pages (from-to)712-720
Number of pages9
JournalCNS Neuroscience and Therapeutics
Volume24
Issue number8
DOIs
Publication statusPublished - Aug 1 2018

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Exploratory Behavior
Circadian Rhythm
Wistar Rats
Central Nervous System
Learning
Pharmaceutical Preparations
Genes
hydroquinone
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
Recognition (Psychology)
serotonin 7 receptor
Spatial Memory

Keywords

  • cognitive memory
  • emotional memory
  • novelty preference
  • novelty seeking
  • synaptic plasticity

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Physiology (medical)
  • Pharmacology (medical)

Cite this

Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters. / Carbone, Cristiana; Adinolfi, Annalisa; Cinque, Stefano; Lacivita, Enza; Alleva, Enrico; Leopoldo, Marcello; Adriani, Walter.

In: CNS Neuroscience and Therapeutics, Vol. 24, No. 8, 01.08.2018, p. 712-720.

Research output: Contribution to journalArticle

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AU - Adinolfi, Annalisa

AU - Cinque, Stefano

AU - Lacivita, Enza

AU - Alleva, Enrico

AU - Leopoldo, Marcello

AU - Adriani, Walter

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