Abstract
Aims: The serotonin 7 receptor (5-HT7R) subtype, coded by Htr7 gene, is broadly expressed in the central nervous system (CNS) with clear involvement in behavioral functions such as learning/memory, regulation of mood, and circadian rhythms. In this study, we assessed effects of 5-HT7R stimulation by administration of its selective agonist, LP-211 (0.25 mg/kg i.p.), in adult Wistar-Han rats. Methods: We used two different explorative-curiosity tests. Drug was administered either before one side-chamber familiarization (CF/V group) or immediately after it, to act on consolidation of familiarization (V/CF group). Results: Exp. 1 for novelty seeking in black/white boxes (BWB), with door opening after 5 minutes in the familiar chamber, showed that (i) time spent in the novel environment (significantly higher than in familiar chamber for controls) is enhanced in V/CF group (potentiated recognition for a “visual” consolidation) and not different in CF/V group; (ii) activity and chamber transitions, made by CF/V rats, are significantly higher than for other groups (interference on recognition for a “spatial” acquisition). Exp. 2 for novelty preference in D- vs L-shaped chambers (D/L), with start from neutral center, gave different results: (i) time spent in the novel environment by CF/V group is significantly higher than other groups (potentiated “cognitive” acquisition); (ii) chamber transitions made by V/CF group are significantly higher than other groups (potentiated “emotional” consolidation). Conclusion: These apparently conflicting results may reflect LP-211 effects on visual vs spatial memory (D/L apparatus has more pronounced hippocampal components than BWB). However, further experiments are needed to analyze more in depth the mechanisms involved.
| Original language | English |
|---|---|
| Pages (from-to) | 712-720 |
| Number of pages | 9 |
| Journal | CNS Neuroscience and Therapeutics |
| Volume | 24 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2018 |
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Keywords
- cognitive memory
- emotional memory
- novelty preference
- novelty seeking
- synaptic plasticity
ASJC Scopus subject areas
- Pharmacology
- Psychiatry and Mental health
- Physiology (medical)
- Pharmacology (medical)
Cite this
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters. / Carbone, Cristiana; Adinolfi, Annalisa; Cinque, Stefano; Lacivita, Enza; Alleva, Enrico; Leopoldo, Marcello; Adriani, Walter.
In: CNS Neuroscience and Therapeutics, Vol. 24, No. 8, 01.08.2018, p. 712-720.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters
AU - Carbone, Cristiana
AU - Adinolfi, Annalisa
AU - Cinque, Stefano
AU - Lacivita, Enza
AU - Alleva, Enrico
AU - Leopoldo, Marcello
AU - Adriani, Walter
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Aims: The serotonin 7 receptor (5-HT7R) subtype, coded by Htr7 gene, is broadly expressed in the central nervous system (CNS) with clear involvement in behavioral functions such as learning/memory, regulation of mood, and circadian rhythms. In this study, we assessed effects of 5-HT7R stimulation by administration of its selective agonist, LP-211 (0.25 mg/kg i.p.), in adult Wistar-Han rats. Methods: We used two different explorative-curiosity tests. Drug was administered either before one side-chamber familiarization (CF/V group) or immediately after it, to act on consolidation of familiarization (V/CF group). Results: Exp. 1 for novelty seeking in black/white boxes (BWB), with door opening after 5 minutes in the familiar chamber, showed that (i) time spent in the novel environment (significantly higher than in familiar chamber for controls) is enhanced in V/CF group (potentiated recognition for a “visual” consolidation) and not different in CF/V group; (ii) activity and chamber transitions, made by CF/V rats, are significantly higher than for other groups (interference on recognition for a “spatial” acquisition). Exp. 2 for novelty preference in D- vs L-shaped chambers (D/L), with start from neutral center, gave different results: (i) time spent in the novel environment by CF/V group is significantly higher than other groups (potentiated “cognitive” acquisition); (ii) chamber transitions made by V/CF group are significantly higher than other groups (potentiated “emotional” consolidation). Conclusion: These apparently conflicting results may reflect LP-211 effects on visual vs spatial memory (D/L apparatus has more pronounced hippocampal components than BWB). However, further experiments are needed to analyze more in depth the mechanisms involved.
AB - Aims: The serotonin 7 receptor (5-HT7R) subtype, coded by Htr7 gene, is broadly expressed in the central nervous system (CNS) with clear involvement in behavioral functions such as learning/memory, regulation of mood, and circadian rhythms. In this study, we assessed effects of 5-HT7R stimulation by administration of its selective agonist, LP-211 (0.25 mg/kg i.p.), in adult Wistar-Han rats. Methods: We used two different explorative-curiosity tests. Drug was administered either before one side-chamber familiarization (CF/V group) or immediately after it, to act on consolidation of familiarization (V/CF group). Results: Exp. 1 for novelty seeking in black/white boxes (BWB), with door opening after 5 minutes in the familiar chamber, showed that (i) time spent in the novel environment (significantly higher than in familiar chamber for controls) is enhanced in V/CF group (potentiated recognition for a “visual” consolidation) and not different in CF/V group; (ii) activity and chamber transitions, made by CF/V rats, are significantly higher than for other groups (interference on recognition for a “spatial” acquisition). Exp. 2 for novelty preference in D- vs L-shaped chambers (D/L), with start from neutral center, gave different results: (i) time spent in the novel environment by CF/V group is significantly higher than other groups (potentiated “cognitive” acquisition); (ii) chamber transitions made by V/CF group are significantly higher than other groups (potentiated “emotional” consolidation). Conclusion: These apparently conflicting results may reflect LP-211 effects on visual vs spatial memory (D/L apparatus has more pronounced hippocampal components than BWB). However, further experiments are needed to analyze more in depth the mechanisms involved.
KW - cognitive memory
KW - emotional memory
KW - novelty preference
KW - novelty seeking
KW - synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=85045682066&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045682066&partnerID=8YFLogxK
U2 - 10.1111/cns.12812
DO - 10.1111/cns.12812
M3 - Article
C2 - 29392842
AN - SCOPUS:85045682066
VL - 24
SP - 712
EP - 720
JO - CNS Neuroscience and Therapeutics
JF - CNS Neuroscience and Therapeutics
SN - 1755-5930
IS - 8
ER -