Activation of blood coagulation in two prototypic autoimmune skin diseases: A possible link with thrombotic risk

Massimo Cugno, Alberto Tedeschi, Alessandro Borghi, Paolo Bucciarelli, Riccardo Asero, Luigia Venegoni, Samantha Griffini, Elena Grovetti, Emilio Berti, Angelo Valerio Marzano

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Coagulation activation has been demonstrated in two prototypic autoimmune skin diseases, chronic autoimmune urticaria and bullous pemphigoid, but only the latter is associated with increased thrombotic risk. Two markers of coagulation activation (prothrombin fragment F1+2 and fibrin fragment D-dimer) were measured by immunoenzymatic methods in plasma samples from 30 patients with active chronic autoimmune urticaria, positive for autologous serum skin test, 30 patients with active bullous pemphigoid and 30 healthy subjects. In skin biopsies, tissue factor expression was evaluated by both immunohistochemistry and in situ hybridization. F1+2 and D-dimer levels were higher in active chronic autoimmune urticaria (276.5±89.8 pmol/L and 5.56±4.40 nmol/L, respectively) than in controls (145.2±38.0 pmol/L and 1.06±0.25 nmol/L; P=0.029 and P=0.011) and were much higher in active bullous pemphigoid (691.7±318.7 pmol/L and 15.24±9.09 nmol/L, respectively) (P

Original languageEnglish
Article numbere0129456
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 9 2015

Fingerprint

urticaria
Bullous Pemphigoid
blood coagulation
Urticaria
skin diseases
Blood Coagulation
Coagulation
Skin Diseases
Autoimmune Diseases
Skin
Blood
Chemical activation
coagulation
prothrombin
skin tests
fibrin
Biopsy
Thromboplastin
blood serum
Skin Tests

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Activation of blood coagulation in two prototypic autoimmune skin diseases : A possible link with thrombotic risk. / Cugno, Massimo; Tedeschi, Alberto; Borghi, Alessandro; Bucciarelli, Paolo; Asero, Riccardo; Venegoni, Luigia; Griffini, Samantha; Grovetti, Elena; Berti, Emilio; Marzano, Angelo Valerio.

In: PLoS One, Vol. 10, No. 6, e0129456, 09.06.2015.

Research output: Contribution to journalArticle

Cugno, Massimo ; Tedeschi, Alberto ; Borghi, Alessandro ; Bucciarelli, Paolo ; Asero, Riccardo ; Venegoni, Luigia ; Griffini, Samantha ; Grovetti, Elena ; Berti, Emilio ; Marzano, Angelo Valerio. / Activation of blood coagulation in two prototypic autoimmune skin diseases : A possible link with thrombotic risk. In: PLoS One. 2015 ; Vol. 10, No. 6.
@article{dd97f1a5bf124db5b0c6f003635717e9,
title = "Activation of blood coagulation in two prototypic autoimmune skin diseases: A possible link with thrombotic risk",
abstract = "Coagulation activation has been demonstrated in two prototypic autoimmune skin diseases, chronic autoimmune urticaria and bullous pemphigoid, but only the latter is associated with increased thrombotic risk. Two markers of coagulation activation (prothrombin fragment F1+2 and fibrin fragment D-dimer) were measured by immunoenzymatic methods in plasma samples from 30 patients with active chronic autoimmune urticaria, positive for autologous serum skin test, 30 patients with active bullous pemphigoid and 30 healthy subjects. In skin biopsies, tissue factor expression was evaluated by both immunohistochemistry and in situ hybridization. F1+2 and D-dimer levels were higher in active chronic autoimmune urticaria (276.5±89.8 pmol/L and 5.56±4.40 nmol/L, respectively) than in controls (145.2±38.0 pmol/L and 1.06±0.25 nmol/L; P=0.029 and P=0.011) and were much higher in active bullous pemphigoid (691.7±318.7 pmol/L and 15.24±9.09 nmol/L, respectively) (P",
author = "Massimo Cugno and Alberto Tedeschi and Alessandro Borghi and Paolo Bucciarelli and Riccardo Asero and Luigia Venegoni and Samantha Griffini and Elena Grovetti and Emilio Berti and Marzano, {Angelo Valerio}",
year = "2015",
month = "6",
day = "9",
doi = "10.1371/journal.pone.0129456",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

TY - JOUR

T1 - Activation of blood coagulation in two prototypic autoimmune skin diseases

T2 - A possible link with thrombotic risk

AU - Cugno, Massimo

AU - Tedeschi, Alberto

AU - Borghi, Alessandro

AU - Bucciarelli, Paolo

AU - Asero, Riccardo

AU - Venegoni, Luigia

AU - Griffini, Samantha

AU - Grovetti, Elena

AU - Berti, Emilio

AU - Marzano, Angelo Valerio

PY - 2015/6/9

Y1 - 2015/6/9

N2 - Coagulation activation has been demonstrated in two prototypic autoimmune skin diseases, chronic autoimmune urticaria and bullous pemphigoid, but only the latter is associated with increased thrombotic risk. Two markers of coagulation activation (prothrombin fragment F1+2 and fibrin fragment D-dimer) were measured by immunoenzymatic methods in plasma samples from 30 patients with active chronic autoimmune urticaria, positive for autologous serum skin test, 30 patients with active bullous pemphigoid and 30 healthy subjects. In skin biopsies, tissue factor expression was evaluated by both immunohistochemistry and in situ hybridization. F1+2 and D-dimer levels were higher in active chronic autoimmune urticaria (276.5±89.8 pmol/L and 5.56±4.40 nmol/L, respectively) than in controls (145.2±38.0 pmol/L and 1.06±0.25 nmol/L; P=0.029 and P=0.011) and were much higher in active bullous pemphigoid (691.7±318.7 pmol/L and 15.24±9.09 nmol/L, respectively) (P

AB - Coagulation activation has been demonstrated in two prototypic autoimmune skin diseases, chronic autoimmune urticaria and bullous pemphigoid, but only the latter is associated with increased thrombotic risk. Two markers of coagulation activation (prothrombin fragment F1+2 and fibrin fragment D-dimer) were measured by immunoenzymatic methods in plasma samples from 30 patients with active chronic autoimmune urticaria, positive for autologous serum skin test, 30 patients with active bullous pemphigoid and 30 healthy subjects. In skin biopsies, tissue factor expression was evaluated by both immunohistochemistry and in situ hybridization. F1+2 and D-dimer levels were higher in active chronic autoimmune urticaria (276.5±89.8 pmol/L and 5.56±4.40 nmol/L, respectively) than in controls (145.2±38.0 pmol/L and 1.06±0.25 nmol/L; P=0.029 and P=0.011) and were much higher in active bullous pemphigoid (691.7±318.7 pmol/L and 15.24±9.09 nmol/L, respectively) (P

UR - http://www.scopus.com/inward/record.url?scp=84936876994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84936876994&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0129456

DO - 10.1371/journal.pone.0129456

M3 - Article

AN - SCOPUS:84936876994

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 6

M1 - e0129456

ER -