Activation of blood coagulation in two prototypic autoimmune skin diseases: A possible link with thrombotic risk

Massimo Cugno, Alberto Tedeschi, Alessandro Borghi, Paolo Bucciarelli, Riccardo Asero, Luigia Venegoni, Samantha Griffini, Elena Grovetti, Emilio Berti, Angelo Valerio Marzano

Research output: Contribution to journalArticle

Abstract

Coagulation activation has been demonstrated in two prototypic autoimmune skin diseases, chronic autoimmune urticaria and bullous pemphigoid, but only the latter is associated with increased thrombotic risk. Two markers of coagulation activation (prothrombin fragment F1+2 and fibrin fragment D-dimer) were measured by immunoenzymatic methods in plasma samples from 30 patients with active chronic autoimmune urticaria, positive for autologous serum skin test, 30 patients with active bullous pemphigoid and 30 healthy subjects. In skin biopsies, tissue factor expression was evaluated by both immunohistochemistry and in situ hybridization. F1+2 and D-dimer levels were higher in active chronic autoimmune urticaria (276.5±89.8 pmol/L and 5.56±4.40 nmol/L, respectively) than in controls (145.2±38.0 pmol/L and 1.06±0.25 nmol/L; P=0.029 and P=0.011) and were much higher in active bullous pemphigoid (691.7±318.7 pmol/L and 15.24±9.09 nmol/L, respectively) (P

Original languageEnglish
Article numbere0129456
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 9 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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