Activation of cerebellar hemispheres in spatial memorization of saccadic eye movements

An fMRI study

Matthias F. Nitschke, Ferdinand Binkofski, Giovanni Buccino, Stefan Posse, Christian Erdmann, Detlef Kömpf, Rüdiger J. Seitz, Wolfgang Heide

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

What mechanisms allow us to direct a precise saccade to a remembered target position in space? The cerebellum has been proposed to be involved not only in motor and oculomotor control, but also in perceptual and cognitive functions. We used functional MRI (Echoplanar imaging at 1.5 T) to investigate the role of the cerebellum in the control of externally triggered and internally generated saccadic eye movements of high and low memory impact, in six healthy volunteers. Memory-guided saccades to remembered locations of 3 targets (triple-step saccades) in contrast to either central fixation or to visually guided saccades activated the cerebellar hemispheres predominantly within lobuli VI-crus I. The same areas were activated when an analogous visuospatial working memory task was contrasted to the triple-step saccades. Visually guided saccades activated the posterior vermis and the triple-step saccades, contrasted to the working memory task, activated predominantly the posterior vermis and paravermal regions. Our data confirm the primary involvement of the posterior vermis for visually-triggered saccadic eye movements and present novel evidence for a role of the cerebellar hemispheres in the mnemonic and visuospatial control of memory-guided saccades.

Original languageEnglish
Pages (from-to)155-164
Number of pages10
JournalHuman Brain Mapping
Volume22
Issue number2
DOIs
Publication statusPublished - Jun 2004

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Saccades
Magnetic Resonance Imaging
Short-Term Memory
Cerebellum
Echo-Planar Imaging
Cognition
Healthy Volunteers

Keywords

  • Cerebellum
  • fMRI
  • Memory-guided
  • Saccades
  • Visually-guided

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Activation of cerebellar hemispheres in spatial memorization of saccadic eye movements : An fMRI study. / Nitschke, Matthias F.; Binkofski, Ferdinand; Buccino, Giovanni; Posse, Stefan; Erdmann, Christian; Kömpf, Detlef; Seitz, Rüdiger J.; Heide, Wolfgang.

In: Human Brain Mapping, Vol. 22, No. 2, 06.2004, p. 155-164.

Research output: Contribution to journalArticle

Nitschke, MF, Binkofski, F, Buccino, G, Posse, S, Erdmann, C, Kömpf, D, Seitz, RJ & Heide, W 2004, 'Activation of cerebellar hemispheres in spatial memorization of saccadic eye movements: An fMRI study', Human Brain Mapping, vol. 22, no. 2, pp. 155-164. https://doi.org/10.1002/hbm.20025
Nitschke, Matthias F. ; Binkofski, Ferdinand ; Buccino, Giovanni ; Posse, Stefan ; Erdmann, Christian ; Kömpf, Detlef ; Seitz, Rüdiger J. ; Heide, Wolfgang. / Activation of cerebellar hemispheres in spatial memorization of saccadic eye movements : An fMRI study. In: Human Brain Mapping. 2004 ; Vol. 22, No. 2. pp. 155-164.
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