Activation of excitatory amino acid receptors reduces thymidine incorporation and cell proliferation rate in primary cultures of astrocytes.

D. F. Condorelli, F. Ingrao, G. Magri, V. Bruno, F. Nicoletti, R. Avola

Research output: Contribution to journalArticle

Abstract

Addition of quisqualate (a heterocyclic analogue of glutamate) reduced [methyl-3H]thymidine incorporation and cell proliferation in primary cultures of rat cortical astrocytes. The inhibitory action of quisqualate was mimicked by glutamate and ibotenate, whereas kainate, N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) were inactive. These results suggest that activation of a specific class of excitatory amino acid receptors contributes to the regulation of growth and proliferation of glial cells in primary culture.

Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalGLIA
Volume2
Issue number1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology

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