Abstract
Addition of quisqualate (a heterocyclic analogue of glutamate) reduced [methyl-3H]thymidine incorporation and cell proliferation in primary cultures of rat cortical astrocytes. The inhibitory action of quisqualate was mimicked by glutamate and ibotenate, whereas kainate, N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) were inactive. These results suggest that activation of a specific class of excitatory amino acid receptors contributes to the regulation of growth and proliferation of glial cells in primary culture.
Original language | English |
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Pages (from-to) | 67-69 |
Number of pages | 3 |
Journal | GLIA |
Volume | 2 |
Issue number | 1 |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- Immunology