Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures

V. Bruno, A. Copani, L. Bonanno, T. Knoepfel, R. Kuhn, P. J. Roberts, F. Nicoletti

Research output: Contribution to journalArticle

Abstract

(RS)-α-Methyl-4-phosphonophenylglycine (MPPG) and (S)-α-methyl-3-carboxyphenylalanine (M3CPA), two novel preferential antagonists of group III metabotropic glutamate (mGlu) receptors, antagonized the neuroprotective activity of L-2-amino-4-phosphonobutanoate (L-AP4) or L-serine-O-phosphate in mice cultured cortical cells exposed to a toxic pulse of N-methyl-D-aspartate. In contrast, MPPG did not influence the neuroprotective activity of the selective group II mGlu receptors agonist, (2(S),1'(R),2'(R),3'(R))-2-(2,3-dicarboxycyclopropyl) glycine (DCG-IV). These results indicate that activation of group m mGlu receptors exerts neuroprotective activity against excitotoxic neuronal death. At least one of the two major group III mGlu receptor subtypes, i.e. mGlu4 receptor, is expressed by cultured cortical neurons, as shown by immunocytochemical analysis with specific polyclonal antibodies.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalEuropean Journal of Pharmacology
Volume310
Issue number1
DOIs
Publication statusPublished - Aug 22 1996

Keywords

  • Cortical neuron
  • Excitotoxicity
  • Metabotropic glutamate receptor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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