TY - JOUR
T1 - Activation of K cells in mice with transplanted tumours differing in immunogenicity and metastasizing capacity
AU - Mantovani, A.
AU - Polentarutti, N.
AU - Alessandri, G.
AU - Vecchi, A.
AU - Giuliani, F.
AU - Spreafico, F.
PY - 1977
Y1 - 1977
N2 - The effector arm of antibody-dependent cellular cytotoxicity (ADCC) was evaluated using 51Cr-labeled chicken erythrocytes as targets in BALB/c mice transplanted with the Moloney sarcoma virus-induced tumors T-MSV and MS2, and in C57BL/6 mice transplanted with the chemically induced FS6 sarcoma, Lewis lung carcinoma and B16 melanoma. Tumor-bearing animals showed higher levels of ADCC than normal mice, a stimulation confirmed in MS2-bearing mice, using SL2 lymphoma cells as targets in a cytostasis assay. ADCC effector-cell capacity was higher in animals transplanted with the immunogenic, spontaneously regressing T-MSV than in mice bearing the poorly immunogenic metastasizing MS2 sarcoma. The increased ADCC activity detectable in the spleen of tumor-bearing hosts was not abolished by removal of phagocytic-adherent cells.
AB - The effector arm of antibody-dependent cellular cytotoxicity (ADCC) was evaluated using 51Cr-labeled chicken erythrocytes as targets in BALB/c mice transplanted with the Moloney sarcoma virus-induced tumors T-MSV and MS2, and in C57BL/6 mice transplanted with the chemically induced FS6 sarcoma, Lewis lung carcinoma and B16 melanoma. Tumor-bearing animals showed higher levels of ADCC than normal mice, a stimulation confirmed in MS2-bearing mice, using SL2 lymphoma cells as targets in a cytostasis assay. ADCC effector-cell capacity was higher in animals transplanted with the immunogenic, spontaneously regressing T-MSV than in mice bearing the poorly immunogenic metastasizing MS2 sarcoma. The increased ADCC activity detectable in the spleen of tumor-bearing hosts was not abolished by removal of phagocytic-adherent cells.
UR - http://www.scopus.com/inward/record.url?scp=0017706611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017706611&partnerID=8YFLogxK
U2 - 10.1038/bjc.1977.214
DO - 10.1038/bjc.1977.214
M3 - Article
C2 - 588412
AN - SCOPUS:0017706611
VL - 36
SP - 453
EP - 460
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 4
ER -