Activation of murine macrophages. I. Different pattern of activation by Poly I: C than by lymphokine or LPS

D. Taramelli, L. Varesio

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of poly I:C to activate mouse macrophages (M∅) to become tumoricidal was evaluated and compared with the ability of 2 other agents, lipopolysaccharide (LPS) and M∅-activating factor (MAF), to induce a tumoricidal state. All these agents were able to stimulate proteose-peptone-elicited M∅ to kill RL♂1 tumor cells in an 18-hr 51Cr release cytotoxicity assay. High levels of cytotoxicity were obtained with concentrations as low as 1 μg/ml of LPS or poly I:C and with 1/81 dilution of MAF. However, in the presence of reagents shown to contain

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalJournal of Immunology
Volume127
Issue number1
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Immunology

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