Abstract
Interaction of the p55 tumor necrosis factor receptor 1 (TNF-R1)- associated signal transducer TRADD with FADD signals apoptosis, whereas the TNF receptor-associated factor 2 protein (TRAF2) is required for activation of the nuclear transcription factor nuclear factor kappa B. TNF-induced activation of the stress-activated protein kinase (SAPK) was shown to occur through a noncytotoxic TRAF2-dependent pathway. TRAF2 was both sufficient and necessary for activation of SAPK by TNF-R1; conversely, expression of a dominant-negative FADD mutant, which blocks apoptosis, did not interfere with SAPK activation. Therefore, SAPK activation occurs through a pathway that is not required for TNF-R1-induced apoptosis.
| Original language | English |
|---|---|
| Pages (from-to) | 200-203 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 275 |
| Issue number | 5297 |
| DOIs | |
| Publication status | Published - Jan 10 1997 |
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Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway. / Natoli, Gioacchino; Costanzo, Antonio; Ianni, Angelo; Templeton, Dennis J.; Woodgett, James R.; Balsano, Clara; Levrero, Massimo.
In: Science, Vol. 275, No. 5297, 10.01.1997, p. 200-203.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway
AU - Natoli, Gioacchino
AU - Costanzo, Antonio
AU - Ianni, Angelo
AU - Templeton, Dennis J.
AU - Woodgett, James R.
AU - Balsano, Clara
AU - Levrero, Massimo
PY - 1997/1/10
Y1 - 1997/1/10
N2 - Interaction of the p55 tumor necrosis factor receptor 1 (TNF-R1)- associated signal transducer TRADD with FADD signals apoptosis, whereas the TNF receptor-associated factor 2 protein (TRAF2) is required for activation of the nuclear transcription factor nuclear factor kappa B. TNF-induced activation of the stress-activated protein kinase (SAPK) was shown to occur through a noncytotoxic TRAF2-dependent pathway. TRAF2 was both sufficient and necessary for activation of SAPK by TNF-R1; conversely, expression of a dominant-negative FADD mutant, which blocks apoptosis, did not interfere with SAPK activation. Therefore, SAPK activation occurs through a pathway that is not required for TNF-R1-induced apoptosis.
AB - Interaction of the p55 tumor necrosis factor receptor 1 (TNF-R1)- associated signal transducer TRADD with FADD signals apoptosis, whereas the TNF receptor-associated factor 2 protein (TRAF2) is required for activation of the nuclear transcription factor nuclear factor kappa B. TNF-induced activation of the stress-activated protein kinase (SAPK) was shown to occur through a noncytotoxic TRAF2-dependent pathway. TRAF2 was both sufficient and necessary for activation of SAPK by TNF-R1; conversely, expression of a dominant-negative FADD mutant, which blocks apoptosis, did not interfere with SAPK activation. Therefore, SAPK activation occurs through a pathway that is not required for TNF-R1-induced apoptosis.
UR - http://www.scopus.com/inward/record.url?scp=0031013545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031013545&partnerID=8YFLogxK
U2 - 10.1126/science.275.5297.200
DO - 10.1126/science.275.5297.200
M3 - Article
C2 - 8985011
AN - SCOPUS:0031013545
VL - 275
SP - 200
EP - 203
JO - Science
JF - Science
SN - 0036-8075
IS - 5297
ER -