Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway

Gioacchino Natoli, Antonio Costanzo, Angelo Ianni, Dennis J. Templeton, James R. Woodgett, Clara Balsano, Massimo Levrero

Research output: Contribution to journalArticlepeer-review

Abstract

Interaction of the p55 tumor necrosis factor receptor 1 (TNF-R1)- associated signal transducer TRADD with FADD signals apoptosis, whereas the TNF receptor-associated factor 2 protein (TRAF2) is required for activation of the nuclear transcription factor nuclear factor kappa B. TNF-induced activation of the stress-activated protein kinase (SAPK) was shown to occur through a noncytotoxic TRAF2-dependent pathway. TRAF2 was both sufficient and necessary for activation of SAPK by TNF-R1; conversely, expression of a dominant-negative FADD mutant, which blocks apoptosis, did not interfere with SAPK activation. Therefore, SAPK activation occurs through a pathway that is not required for TNF-R1-induced apoptosis.

Original languageEnglish
Pages (from-to)200-203
Number of pages4
JournalScience
Volume275
Issue number5297
DOIs
Publication statusPublished - Jan 10 1997

ASJC Scopus subject areas

  • General

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