Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway

Gioacchino Natoli, Antonio Costanzo, Angelo Ianni, Dennis J. Templeton, James R. Woodgett, Clara Balsano, Massimo Levrero

Research output: Contribution to journalArticle

398 Citations (Scopus)

Abstract

Interaction of the p55 tumor necrosis factor receptor 1 (TNF-R1)- associated signal transducer TRADD with FADD signals apoptosis, whereas the TNF receptor-associated factor 2 protein (TRAF2) is required for activation of the nuclear transcription factor nuclear factor kappa B. TNF-induced activation of the stress-activated protein kinase (SAPK) was shown to occur through a noncytotoxic TRAF2-dependent pathway. TRAF2 was both sufficient and necessary for activation of SAPK by TNF-R1; conversely, expression of a dominant-negative FADD mutant, which blocks apoptosis, did not interfere with SAPK activation. Therefore, SAPK activation occurs through a pathway that is not required for TNF-R1-induced apoptosis.

Original languageEnglish
Pages (from-to)200-203
Number of pages4
JournalScience
Volume275
Issue number5297
DOIs
Publication statusPublished - Jan 10 1997

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TNF Receptor-Associated Factor 2
Tumor Necrosis Factor Receptors
Heat-Shock Proteins
Protein Kinases
Apoptosis
Proteins
NF-kappa B
Transducers
Transcription Factors

ASJC Scopus subject areas

  • General

Cite this

Natoli, G., Costanzo, A., Ianni, A., Templeton, D. J., Woodgett, J. R., Balsano, C., & Levrero, M. (1997). Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway. Science, 275(5297), 200-203. https://doi.org/10.1126/science.275.5297.200

Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway. / Natoli, Gioacchino; Costanzo, Antonio; Ianni, Angelo; Templeton, Dennis J.; Woodgett, James R.; Balsano, Clara; Levrero, Massimo.

In: Science, Vol. 275, No. 5297, 10.01.1997, p. 200-203.

Research output: Contribution to journalArticle

Natoli, G, Costanzo, A, Ianni, A, Templeton, DJ, Woodgett, JR, Balsano, C & Levrero, M 1997, 'Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway', Science, vol. 275, no. 5297, pp. 200-203. https://doi.org/10.1126/science.275.5297.200
Natoli G, Costanzo A, Ianni A, Templeton DJ, Woodgett JR, Balsano C et al. Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway. Science. 1997 Jan 10;275(5297):200-203. https://doi.org/10.1126/science.275.5297.200
Natoli, Gioacchino ; Costanzo, Antonio ; Ianni, Angelo ; Templeton, Dennis J. ; Woodgett, James R. ; Balsano, Clara ; Levrero, Massimo. / Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway. In: Science. 1997 ; Vol. 275, No. 5297. pp. 200-203.
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