Activation of the hemostatic system during thrombolytic therapy

Piera Angelica Merlini, Marco Cattaneo, Alessandra Spinpla, Diego Ardissino, Luigi Oltrona, Carlo Belli, Pier Mannuccio Mannucci

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Activation of the hemostatic mechanism has been described during thrombolytic therapy. This phenomenon has been detected by new methods of assessing hemostatic system function, based on immunoenzymatic or radioimmunoassays. However, these methods are extremely sensitive and, unless they are performed in expert laboratories, carefully following the recommended procedures, they generate in vitro artifacts. A description of these methods is provided, as well as a critical review of the available studies. The correct use of these methods will provide us with an understanding of the complex response of the hemostatic system to pharmacologie thrombolysis.

Original languageEnglish
JournalThe American Journal of Cardiology
Issue number19
Publication statusPublished - Dec 16 1993

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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