Activation of the plasma coagulation system induced by some biomaterials

E. Cenni, G. Ciapetti, M. Cervellati, D. Cavedagna, G. Falsone, S. Gamberini, A. Pizzoferrato

Research output: Contribution to journalArticlepeer-review


The ability of some biomaterials to activate plasma coagulation system was examined in vitro. After contact of platelet-rich plasma with biomaterials, some markers of the thrombin formation process, i.e., fragment 1 + 2 and fibrinopeptide A, and some inhibitors of the blood coagulation mechanism were tested. Fragment 1 + 2 and fibrinopeptide A were found to be increased by all of the materials, though to a different extent. In particular, fragment 1 + 2 and fibrinopeptide A were significantly increased upon contact with polybutylene terephthalate and with collagen coated polyethylene terephthalate, respectively. Also, antithrombin III was shown to decrease following exposure to biomaterials, but statistical significance was found only for polyethylene terephthalate and polyvinylacetate. As a result of this wide range of variability in the parameters, it is advisable to explore the plasma coagulation system with a multiparametric approach in which thrombin formation and coagulation inhibitors are thoroughly investigated.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalJournal of Biomedical Materials Research
Issue number1
Publication statusPublished - May 1996

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials


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