Activation of the prefrontal cortex during a visual n-back working memory task with varying memory load: A near infrared spectroscopy study

Erika Molteni, Michele Butt, Anna M. Bianchi, Gianluigi Reni

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We evaluated frontal brain activation during a Working Memory task with graded levels of difficulty in a group of 15 healthy subjects, by means of fNIRS technique. Brain activation (% signal change with respect to the baseline) was computed and load-related increases of blood oxygenation were found for the four different levels of task difficulty. Generalized Linear Models were applied to the data in order to evaluate the metabolic processes occurring during the mental effort and, possibly, their involvement in short term memorization. The Cognitive Failure Questionnaire was also administered in order to assess its diagnostic relevance in clinics. Results attest a monotous increase of brain oxygenation with WM load during the first half of task, persisting through the central resting period and prevailing in the left hemisphere. Decreasing WM load is also coupled with oxygenated hemoglobin decrease.

Original languageEnglish
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
Pages4024-4027
Number of pages4
Publication statusPublished - 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

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    Molteni, E., Butt, M., Bianchi, A. M., & Reni, G. (2008). Activation of the prefrontal cortex during a visual n-back working memory task with varying memory load: A near infrared spectroscopy study. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology" (pp. 4024-4027). [4650092]