Activation of the protein C pathway in hereditary thrombophilia

Elena M. Faioni, Franca Franchi, Daniela Asti, Pier Mannuccio Mannucci

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Levels of free activated protein C are a measure of the activation of the protein C pathway in vivo. The aim of this study was to establish if the protein C pathway is triggered in familial thrombophilia and if activated protein C levels correlate with type of defect or symptoms. We measured activated protein C in 133 patients with a deficiency of antithrombin (n = 31), protein C (n = 24) or protein S (n = 27) or with resistance to activated protein C (n = 51). Levels of activated protein C were evaluated also in 97 healthy individuals. Results indicate that the levels of activated protein C are higher in patients who have experienced a thrombotic event than in patients who have not and that 71% of patients with levels of activated protein C above the normal reference range had had a venous thromboembolic event. We conclude that the protein C pathway is triggered in patients with thrombophilia and that in symptomatic patients, activated protein C levels are increased and may reflect heightened coagulation activation and scavenging through the protein C pathway.

Original languageEnglish
Pages (from-to)557-560
Number of pages4
JournalThrombosis and Haemostasis
Volume80
Issue number4
Publication statusPublished - Oct 1998

Fingerprint

Protein C
Thrombophilia
Hereditary Thrombophilia
Reference Values
Activated Protein C Resistance
Antithrombins
Protein S

ASJC Scopus subject areas

  • Hematology

Cite this

Activation of the protein C pathway in hereditary thrombophilia. / Faioni, Elena M.; Franchi, Franca; Asti, Daniela; Mannucci, Pier Mannuccio.

In: Thrombosis and Haemostasis, Vol. 80, No. 4, 10.1998, p. 557-560.

Research output: Contribution to journalArticle

Faioni, EM, Franchi, F, Asti, D & Mannucci, PM 1998, 'Activation of the protein C pathway in hereditary thrombophilia', Thrombosis and Haemostasis, vol. 80, no. 4, pp. 557-560.
Faioni, Elena M. ; Franchi, Franca ; Asti, Daniela ; Mannucci, Pier Mannuccio. / Activation of the protein C pathway in hereditary thrombophilia. In: Thrombosis and Haemostasis. 1998 ; Vol. 80, No. 4. pp. 557-560.
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