Activation of the ret oncogene in human thyroid carcinomas

Domenico Salvatore, Massimo Santoro, Michèle Grieco, Gianfranco Fenzi, Vieri Galli, Alfredo Fusco, Giancarlo Vecchio, G. Salvatore

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A novel oncogene has been recently found activated in human thyroid carcinomas. This oncogene was named RET/PTC and was shown to be a chimeric gene, product of the fusion of the tyrosinekinase domain or the RET proto-oncogene to the 5'-terminal region of another gene named H4 or D10S170. A paracentric inversion (10) (q 11.2-21) was demonstrated to be responsible for the H4/RET fusion. Thyroid tumors consist of a broad range of lesions ranging from the benign follicular adenomas to the differentiated papillary and follicular carcinomas and to the fatal anaplastic carcinomas. Papillary and follicular carcinomas have different clinical behaviours and are associated with different risk factors, thus they are probably related to different genetic events. In fact the activation of RET is restricted to the papillary subtype. Here we show the activation of the RET oncogene in 2 out of 10 new cases of papillary thyroid carcinomas.

Original languageEnglish
Pages (from-to)367-375
Number of pages9
JournalRendiconti Lincei
Volume4
Issue number4
DOIs
Publication statusPublished - Dec 1993

Fingerprint

oncogenes
Carcinoma, Papillary, Follicular
Oncogenes
Thyroid Neoplasms
carcinoma
Fusion reactions
Genes
Chemical activation
gene
risk factor
lesion
tumor
Tumors
Factor IX
Proto-Oncogenes
Gene Fusion
Adenoma
paracentric inversion
Thyroid Gland
proto-oncogenes

Keywords

  • Gene rearrangement
  • Oncogene
  • Thyroid carcinoma

ASJC Scopus subject areas

  • Engineering(all)
  • Environmental Science(all)
  • Earth and Planetary Sciences(all)
  • Agricultural and Biological Sciences(all)

Cite this

Salvatore, D., Santoro, M., Grieco, M., Fenzi, G., Galli, V., Fusco, A., ... Salvatore, G. (1993). Activation of the ret oncogene in human thyroid carcinomas. Rendiconti Lincei, 4(4), 367-375. https://doi.org/10.1007/BF03001196

Activation of the ret oncogene in human thyroid carcinomas. / Salvatore, Domenico; Santoro, Massimo; Grieco, Michèle; Fenzi, Gianfranco; Galli, Vieri; Fusco, Alfredo; Vecchio, Giancarlo; Salvatore, G.

In: Rendiconti Lincei, Vol. 4, No. 4, 12.1993, p. 367-375.

Research output: Contribution to journalArticle

Salvatore, D, Santoro, M, Grieco, M, Fenzi, G, Galli, V, Fusco, A, Vecchio, G & Salvatore, G 1993, 'Activation of the ret oncogene in human thyroid carcinomas', Rendiconti Lincei, vol. 4, no. 4, pp. 367-375. https://doi.org/10.1007/BF03001196
Salvatore D, Santoro M, Grieco M, Fenzi G, Galli V, Fusco A et al. Activation of the ret oncogene in human thyroid carcinomas. Rendiconti Lincei. 1993 Dec;4(4):367-375. https://doi.org/10.1007/BF03001196
Salvatore, Domenico ; Santoro, Massimo ; Grieco, Michèle ; Fenzi, Gianfranco ; Galli, Vieri ; Fusco, Alfredo ; Vecchio, Giancarlo ; Salvatore, G. / Activation of the ret oncogene in human thyroid carcinomas. In: Rendiconti Lincei. 1993 ; Vol. 4, No. 4. pp. 367-375.
@article{d1b2c12d9d134390bc27e260face0885,
title = "Activation of the ret oncogene in human thyroid carcinomas",
abstract = "A novel oncogene has been recently found activated in human thyroid carcinomas. This oncogene was named RET/PTC and was shown to be a chimeric gene, product of the fusion of the tyrosinekinase domain or the RET proto-oncogene to the 5'-terminal region of another gene named H4 or D10S170. A paracentric inversion (10) (q 11.2-21) was demonstrated to be responsible for the H4/RET fusion. Thyroid tumors consist of a broad range of lesions ranging from the benign follicular adenomas to the differentiated papillary and follicular carcinomas and to the fatal anaplastic carcinomas. Papillary and follicular carcinomas have different clinical behaviours and are associated with different risk factors, thus they are probably related to different genetic events. In fact the activation of RET is restricted to the papillary subtype. Here we show the activation of the RET oncogene in 2 out of 10 new cases of papillary thyroid carcinomas.",
keywords = "Gene rearrangement, Oncogene, Thyroid carcinoma",
author = "Domenico Salvatore and Massimo Santoro and Mich{\`e}le Grieco and Gianfranco Fenzi and Vieri Galli and Alfredo Fusco and Giancarlo Vecchio and G. Salvatore",
year = "1993",
month = "12",
doi = "10.1007/BF03001196",
language = "English",
volume = "4",
pages = "367--375",
journal = "ATTI Della Accademia Nazionale Dei Lincei Rendiconti Lincei Scienze Fisiche E Naturali",
issn = "2037-4631",
publisher = "Accademia Nazionale dei Lincei",
number = "4",

}

TY - JOUR

T1 - Activation of the ret oncogene in human thyroid carcinomas

AU - Salvatore, Domenico

AU - Santoro, Massimo

AU - Grieco, Michèle

AU - Fenzi, Gianfranco

AU - Galli, Vieri

AU - Fusco, Alfredo

AU - Vecchio, Giancarlo

AU - Salvatore, G.

PY - 1993/12

Y1 - 1993/12

N2 - A novel oncogene has been recently found activated in human thyroid carcinomas. This oncogene was named RET/PTC and was shown to be a chimeric gene, product of the fusion of the tyrosinekinase domain or the RET proto-oncogene to the 5'-terminal region of another gene named H4 or D10S170. A paracentric inversion (10) (q 11.2-21) was demonstrated to be responsible for the H4/RET fusion. Thyroid tumors consist of a broad range of lesions ranging from the benign follicular adenomas to the differentiated papillary and follicular carcinomas and to the fatal anaplastic carcinomas. Papillary and follicular carcinomas have different clinical behaviours and are associated with different risk factors, thus they are probably related to different genetic events. In fact the activation of RET is restricted to the papillary subtype. Here we show the activation of the RET oncogene in 2 out of 10 new cases of papillary thyroid carcinomas.

AB - A novel oncogene has been recently found activated in human thyroid carcinomas. This oncogene was named RET/PTC and was shown to be a chimeric gene, product of the fusion of the tyrosinekinase domain or the RET proto-oncogene to the 5'-terminal region of another gene named H4 or D10S170. A paracentric inversion (10) (q 11.2-21) was demonstrated to be responsible for the H4/RET fusion. Thyroid tumors consist of a broad range of lesions ranging from the benign follicular adenomas to the differentiated papillary and follicular carcinomas and to the fatal anaplastic carcinomas. Papillary and follicular carcinomas have different clinical behaviours and are associated with different risk factors, thus they are probably related to different genetic events. In fact the activation of RET is restricted to the papillary subtype. Here we show the activation of the RET oncogene in 2 out of 10 new cases of papillary thyroid carcinomas.

KW - Gene rearrangement

KW - Oncogene

KW - Thyroid carcinoma

UR - http://www.scopus.com/inward/record.url?scp=65749310279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65749310279&partnerID=8YFLogxK

U2 - 10.1007/BF03001196

DO - 10.1007/BF03001196

M3 - Article

VL - 4

SP - 367

EP - 375

JO - ATTI Della Accademia Nazionale Dei Lincei Rendiconti Lincei Scienze Fisiche E Naturali

JF - ATTI Della Accademia Nazionale Dei Lincei Rendiconti Lincei Scienze Fisiche E Naturali

SN - 2037-4631

IS - 4

ER -