Activators and inhibitors of the fibrinolytic system in maturity-onset diabetes mellitus without thromboembolic manifestations

Gabriella Gamba, Guido Grignani, Vincenzo Montera, Gianna Perotti, Livio Ragone, Edoardo Ascari

Research output: Contribution to journalArticle

Abstract

In patients with maturity-onset diabetes mellitus without thromboembolic manifestations, significant increases in both fibrinolytic and antifibrinolytic activity were demonstrated. The increased fibrinolytic activity observed under basal conditions could be due to the continuous release of plasminogen activators from damaged endothelial cells. This hypothesis is supported by the fact that the higher fibrinolytic activity observed in diabetics is followed by a lesser increase in fibrinolytic activity than in controls after the venous occlusion test. The main antiplasmins, except α2-antiplasmin, were significantly higher in diabetics, and their levels were not affected by sex, metabolic regulation, retinopathy, duration of the disease or cholesterolemia. On the contrary, weight, therapy and triglyceridemia significantly influenced the levels of some anti-plasmins. Furthermore, hypertriglyceridemia and hypercholesterolemia were associated with a reduction of fibrinolysis. Thus, these conditions may further increase the risk of thromboembolic complications of diabetes mellitus.

Original languageEnglish
Pages (from-to)337-347
Number of pages11
JournalLa Ricerca in Clinica e in Laboratorio
Volume13
Issue number3
DOIs
Publication statusPublished - Jul 1983

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Keywords

  • Diabetes mellitus
  • Fibrinolysis inhibitors
  • Fibrinolytic activity
  • Thromboembolic manifestations

ASJC Scopus subject areas

  • Clinical Biochemistry

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