Activatory properties of lysophosphatidic acid on human THP-1 cells

F. D'Aquilio, M. Procaccini, V. Izzi, V. Chiurchiu', V. Giambra, F. Carotenuto, P. Di Nardo, P. M. Baldini

Research output: Contribution to journalArticlepeer-review

Abstract

Excessive leukocyte proliferation and proinflammatory mediators release represent common phenomena in several chronic inflammatory diseases. Multiple evidences identify lysophosphatidic acid (LPA), a small lipid endowed with pleiotropic activities, as an important modulator of both proliferation and activation of different cell types involved in several inflammation-associated pathologies. However, its possible role on monocyte proinflammatory activation is not fully understood yet. Aim of the present study was to investigate LPA effects on THP-1 cells in terms of proliferation, reactive oxygen intermediates (ROI) production and release of arachidonic acid-derived inflammatory mediators. Actually, LPA significantly increased both DNA synthesis and ROI production as well as prostaglandin E2 release and the upregulation of LPA 3 receptor expression. These findings identified LPA as both a growth factor and a triggering mediator of proinflammatory response in THP-1 cells.

Original languageEnglish
Pages (from-to)167-177
Number of pages11
JournalInflammation
Volume30
Issue number5
DOIs
Publication statusPublished - Oct 2007

Keywords

  • Arachidonic acid metabolites
  • LPA receptors
  • Lysophosphatidic acid
  • Proliferation
  • Reactive oxygen intermediates

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology
  • Cell Biology

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