Activatory properties of lysophosphatidic acid on human THP-1 cells

F. D'Aquilio, M. Procaccini, V. Izzi, V. Chiurchiu', V. Giambra, F. Carotenuto, P. Di Nardo, P. M. Baldini

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Excessive leukocyte proliferation and proinflammatory mediators release represent common phenomena in several chronic inflammatory diseases. Multiple evidences identify lysophosphatidic acid (LPA), a small lipid endowed with pleiotropic activities, as an important modulator of both proliferation and activation of different cell types involved in several inflammation-associated pathologies. However, its possible role on monocyte proinflammatory activation is not fully understood yet. Aim of the present study was to investigate LPA effects on THP-1 cells in terms of proliferation, reactive oxygen intermediates (ROI) production and release of arachidonic acid-derived inflammatory mediators. Actually, LPA significantly increased both DNA synthesis and ROI production as well as prostaglandin E2 release and the upregulation of LPA 3 receptor expression. These findings identified LPA as both a growth factor and a triggering mediator of proinflammatory response in THP-1 cells.

Original languageEnglish
Pages (from-to)129-140
Number of pages12
JournalInflammation
Volume29
Issue number4-6
DOIs
Publication statusPublished - Dec 2005

Fingerprint

Lysophosphatidic Acid Receptors
Oxygen
Dinoprostone
Arachidonic Acid
Monocytes
Intercellular Signaling Peptides and Proteins
Leukocytes
Chronic Disease
Up-Regulation
Pathology
Inflammation
Lipids
lysophosphatidic acid
DNA

Keywords

  • Arachidonic acid metabolites
  • LPA receptors
  • Lysophosphatidic acid
  • Proliferation
  • Reactive oxygen intermediates

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology
  • Cell Biology

Cite this

D'Aquilio, F., Procaccini, M., Izzi, V., Chiurchiu', V., Giambra, V., Carotenuto, F., ... Baldini, P. M. (2005). Activatory properties of lysophosphatidic acid on human THP-1 cells. Inflammation, 29(4-6), 129-140. https://doi.org/10.1007/s10753-006-9008-9

Activatory properties of lysophosphatidic acid on human THP-1 cells. / D'Aquilio, F.; Procaccini, M.; Izzi, V.; Chiurchiu', V.; Giambra, V.; Carotenuto, F.; Di Nardo, P.; Baldini, P. M.

In: Inflammation, Vol. 29, No. 4-6, 12.2005, p. 129-140.

Research output: Contribution to journalArticle

D'Aquilio, F, Procaccini, M, Izzi, V, Chiurchiu', V, Giambra, V, Carotenuto, F, Di Nardo, P & Baldini, PM 2005, 'Activatory properties of lysophosphatidic acid on human THP-1 cells', Inflammation, vol. 29, no. 4-6, pp. 129-140. https://doi.org/10.1007/s10753-006-9008-9
D'Aquilio F, Procaccini M, Izzi V, Chiurchiu' V, Giambra V, Carotenuto F et al. Activatory properties of lysophosphatidic acid on human THP-1 cells. Inflammation. 2005 Dec;29(4-6):129-140. https://doi.org/10.1007/s10753-006-9008-9
D'Aquilio, F. ; Procaccini, M. ; Izzi, V. ; Chiurchiu', V. ; Giambra, V. ; Carotenuto, F. ; Di Nardo, P. ; Baldini, P. M. / Activatory properties of lysophosphatidic acid on human THP-1 cells. In: Inflammation. 2005 ; Vol. 29, No. 4-6. pp. 129-140.
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