Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort

Laure Dossus, Marie Christine Boutron-Ruault, Rudolf Kaaks, Inger T. Gram, Alice Vilier, Béatrice Fervers, Jonas Manjer, Anne Tjonneland, Anja Olsen, Kim Overvad, Jenny Chang-Claude, Heiner Boeing, Annika Steffen, Antonia Trichopoulou, Pagona Lagiou, Maria Sarantopoulou, Domenico Palli, Franco Berrino, Rosario Tumino, Paolo VineisAmalia Mattiello, H. Bas Bueno-De-Mesquita, Franzel J B Van Duijnhoven, Marieke F. Bakker, Petra Hm Peeters, Elisabete Weiderpass, Eivind Bjerkaas, Tonje Braaten, Virginia Menéndez, Antonio Agudo, Maria Jose Sanchez, Pilar Amiano, Maria Jose Tormo, Aurelio Barricarte, Salma Butt, Kay Tee Khaw, Nicholas Wareham, Tim J. Key, Ruth C. Travis, Sabina Rinaldi, Valerie McCormack, Isabelle Romieu, David G. Cox, Teresa Norat, Elio Riboli, Françoise Clavel-Chapelon

Research output: Contribution to journalArticle

Abstract

Recent cohort studies suggest that increased breast cancer risks were associated with longer smoking duration, higher pack-years and a dose-response relationship with increasing pack-years of smoking between menarche and first full-term pregnancy (FFTP). Studies with comprehensive quantitative life-time measures of passive smoking suggest an association between passive smoking dose and breast cancer risk. We conducted a study within the European Prospective Investigation into Cancer and Nutrition to examine the association between passive and active smoking and risk of invasive breast cancer and possible effect modification by known breast cancer risk factors. Among the 322,988 women eligible for the study, 9,822 developed breast cancer (183,608 women with passive smoking information including 6,264 cases). When compared to women who never smoked and were not being exposed to passive smoking at home or work at the time of study registration, current, former and currently exposed passive smokers were at increased risk of breast cancer (hazard ratios (HR) [95% confidence interval (CI)] 1.16 [1.05-1.28], 1.14 [1.04-1.25] and 1.10 [1.01-1.20], respectively). Analyses exploring associations in different periods of life showed the most important increase in risk with pack-years from menarche to FFTP (1.73 [1.29-2.32] for every increase of 20 pack-years) while pack-years smoked after menopause were associated with a significant decrease in breast cancer risk (HR = 0.53, 95% CI: 0.34-0.82 for every increase of 20 pack-years). Our results provide an important replication, in the largest cohort to date, that smoking (passively or actively) increases breast cancer risk and that smoking between menarche and FFTP is particularly deleterious. What's new? The EPIC study is the largest cohort analysis on smoking and breast cancer to date. In this analysis of data from that study, the authors have confirmed that both active and passive exposure to cigarette smoke increases breast cancer risk. These results emphasize that it's important to distinguish between passive exposure and no exposure when analyzing the relationship between smoking and breast cancer. The authors also confirm that the most potent window of exposure for smoking and breast cancer risk is between menarche and first full term pregnancy.

Original languageEnglish
Pages (from-to)1871-1888
Number of pages18
JournalInternational Journal of Cancer
Volume134
Issue number8
DOIs
Publication statusPublished - Apr 15 2014

Keywords

  • breast cancer
  • prospective
  • second-hand smoke
  • tobacco smoke

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Dossus, L., Boutron-Ruault, M. C., Kaaks, R., Gram, I. T., Vilier, A., Fervers, B., Manjer, J., Tjonneland, A., Olsen, A., Overvad, K., Chang-Claude, J., Boeing, H., Steffen, A., Trichopoulou, A., Lagiou, P., Sarantopoulou, M., Palli, D., Berrino, F., Tumino, R., ... Clavel-Chapelon, F. (2014). Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort. International Journal of Cancer, 134(8), 1871-1888. https://doi.org/10.1002/ijc.28508