Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort

Laure Dossus; Marie Christine Boutron-Ruault; Rudolf Kaaks; Inger T. Gram; Alice Vilier; Béatrice Fervers; Jonas Manjer; Anne Tjonneland; Anja Olsen; Kim Overvad; Jenny Chang-Claude; Heiner Boeing; Annika Steffen; Antonia Trichopoulou; Pagona Lagiou; Maria Sarantopoulou; Domenico Palli; Franco Berrino; Rosario Tumino; Paolo Vineis; Amalia Mattiello; H. Bas Bueno-De-Mesquita; Franzel J B Van Duijnhoven; Marieke F. Bakker; Petra Hm Peeters; Elisabete Weiderpass; Eivind Bjerkaas; Tonje Braaten; Virginia Menéndez; Antonio Agudo; Maria Jose Sanchez; Pilar Amiano; Maria Jose Tormo; Aurelio Barricarte; Salma Butt; Kay Tee Khaw; Nicholas Wareham; Tim J. Key; Ruth C. Travis; Sabina Rinaldi; Valerie McCormack; Isabelle Romieu; David G. Cox; Teresa Norat; Elio Riboli; Françoise Clavel-Chapelon

doi:10.1002/ijc.28508

Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort

Laure Dossus, Marie Christine Boutron-Ruault, Rudolf Kaaks, Inger T. Gram, Alice Vilier, Béatrice Fervers, Jonas Manjer, Anne Tjonneland, Anja Olsen, Kim Overvad, Jenny Chang-Claude, Heiner Boeing, Annika Steffen, Antonia Trichopoulou, Pagona Lagiou, Maria Sarantopoulou, Domenico Palli, Franco Berrino, Rosario Tumino, Paolo VineisAmalia Mattiello, H. Bas Bueno-De-Mesquita, Franzel J B Van Duijnhoven, Marieke F. Bakker, Petra Hm Peeters, Elisabete Weiderpass, Eivind Bjerkaas, Tonje Braaten, Virginia Menéndez, Antonio Agudo, Maria Jose Sanchez, Pilar Amiano, Maria Jose Tormo, Aurelio Barricarte, Salma Butt, Kay Tee Khaw, Nicholas Wareham, Tim J. Key, Ruth C. Travis, Sabina Rinaldi, Valerie McCormack, Isabelle Romieu, David G. Cox, Teresa Norat, Elio Riboli, Françoise Clavel-Chapelon

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article

Abstract

Recent cohort studies suggest that increased breast cancer risks were associated with longer smoking duration, higher pack-years and a dose-response relationship with increasing pack-years of smoking between menarche and first full-term pregnancy (FFTP). Studies with comprehensive quantitative life-time measures of passive smoking suggest an association between passive smoking dose and breast cancer risk. We conducted a study within the European Prospective Investigation into Cancer and Nutrition to examine the association between passive and active smoking and risk of invasive breast cancer and possible effect modification by known breast cancer risk factors. Among the 322,988 women eligible for the study, 9,822 developed breast cancer (183,608 women with passive smoking information including 6,264 cases). When compared to women who never smoked and were not being exposed to passive smoking at home or work at the time of study registration, current, former and currently exposed passive smokers were at increased risk of breast cancer (hazard ratios (HR) [95% confidence interval (CI)] 1.16 [1.05-1.28], 1.14 [1.04-1.25] and 1.10 [1.01-1.20], respectively). Analyses exploring associations in different periods of life showed the most important increase in risk with pack-years from menarche to FFTP (1.73 [1.29-2.32] for every increase of 20 pack-years) while pack-years smoked after menopause were associated with a significant decrease in breast cancer risk (HR = 0.53, 95% CI: 0.34-0.82 for every increase of 20 pack-years). Our results provide an important replication, in the largest cohort to date, that smoking (passively or actively) increases breast cancer risk and that smoking between menarche and FFTP is particularly deleterious. What's new? The EPIC study is the largest cohort analysis on smoking and breast cancer to date. In this analysis of data from that study, the authors have confirmed that both active and passive exposure to cigarette smoke increases breast cancer risk. These results emphasize that it's important to distinguish between passive exposure and no exposure when analyzing the relationship between smoking and breast cancer. The authors also confirm that the most potent window of exposure for smoking and breast cancer risk is between menarche and first full term pregnancy.

Original language	English
Pages (from-to)	1871-1888
Number of pages	18
Journal	International Journal of Cancer
Volume	134
Issue number	8
DOIs	https://doi.org/10.1002/ijc.28508
Publication status	Published - Apr 15 2014

Keywords

breast cancer
prospective
second-hand smoke
tobacco smoke

ASJC Scopus subject areas

Cancer Research
Oncology

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Dossus, L., Boutron-Ruault, M. C., Kaaks, R., Gram, I. T., Vilier, A., Fervers, B., Manjer, J., Tjonneland, A., Olsen, A., Overvad, K., Chang-Claude, J., Boeing, H., Steffen, A., Trichopoulou, A., Lagiou, P., Sarantopoulou, M., Palli, D., Berrino, F., Tumino, R., ... Clavel-Chapelon, F. (2014). Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort. International Journal of Cancer, 134(8), 1871-1888. https://doi.org/10.1002/ijc.28508

Active and passive cigarette smoking and breast cancer risk : Results from the EPIC cohort. / Dossus, Laure; Boutron-Ruault, Marie Christine; Kaaks, Rudolf; Gram, Inger T.; Vilier, Alice; Fervers, Béatrice; Manjer, Jonas; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Chang-Claude, Jenny; Boeing, Heiner; Steffen, Annika; Trichopoulou, Antonia; Lagiou, Pagona; Sarantopoulou, Maria; Palli, Domenico; Berrino, Franco; Tumino, Rosario; Vineis, Paolo; Mattiello, Amalia; Bueno-De-Mesquita, H. Bas; Van Duijnhoven, Franzel J B; Bakker, Marieke F.; Peeters, Petra Hm; Weiderpass, Elisabete; Bjerkaas, Eivind; Braaten, Tonje; Menéndez, Virginia; Agudo, Antonio; Sanchez, Maria Jose; Amiano, Pilar; Tormo, Maria Jose; Barricarte, Aurelio; Butt, Salma; Khaw, Kay Tee; Wareham, Nicholas; Key, Tim J.; Travis, Ruth C.; Rinaldi, Sabina; McCormack, Valerie; Romieu, Isabelle; Cox, David G.; Norat, Teresa; Riboli, Elio; Clavel-Chapelon, Françoise.

In: International Journal of Cancer, Vol. 134, No. 8, 15.04.2014, p. 1871-1888.

Research output: Contribution to journal › Article

Dossus, L, Boutron-Ruault, MC, Kaaks, R, Gram, IT, Vilier, A, Fervers, B, Manjer, J, Tjonneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Boeing, H, Steffen, A, Trichopoulou, A, Lagiou, P, Sarantopoulou, M, Palli, D, Berrino, F, Tumino, R, Vineis, P, Mattiello, A, Bueno-De-Mesquita, HB, Van Duijnhoven, FJB, Bakker, MF, Peeters, PH, Weiderpass, E, Bjerkaas, E, Braaten, T, Menéndez, V, Agudo, A, Sanchez, MJ, Amiano, P, Tormo, MJ, Barricarte, A, Butt, S, Khaw, KT, Wareham, N, Key, TJ, Travis, RC, Rinaldi, S, McCormack, V, Romieu, I, Cox, DG, Norat, T, Riboli, E & Clavel-Chapelon, F 2014, 'Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort', International Journal of Cancer, vol. 134, no. 8, pp. 1871-1888. https://doi.org/10.1002/ijc.28508

Dossus, Laure ; Boutron-Ruault, Marie Christine ; Kaaks, Rudolf ; Gram, Inger T. ; Vilier, Alice ; Fervers, Béatrice ; Manjer, Jonas ; Tjonneland, Anne ; Olsen, Anja ; Overvad, Kim ; Chang-Claude, Jenny ; Boeing, Heiner ; Steffen, Annika ; Trichopoulou, Antonia ; Lagiou, Pagona ; Sarantopoulou, Maria ; Palli, Domenico ; Berrino, Franco ; Tumino, Rosario ; Vineis, Paolo ; Mattiello, Amalia ; Bueno-De-Mesquita, H. Bas ; Van Duijnhoven, Franzel J B ; Bakker, Marieke F. ; Peeters, Petra Hm ; Weiderpass, Elisabete ; Bjerkaas, Eivind ; Braaten, Tonje ; Menéndez, Virginia ; Agudo, Antonio ; Sanchez, Maria Jose ; Amiano, Pilar ; Tormo, Maria Jose ; Barricarte, Aurelio ; Butt, Salma ; Khaw, Kay Tee ; Wareham, Nicholas ; Key, Tim J. ; Travis, Ruth C. ; Rinaldi, Sabina ; McCormack, Valerie ; Romieu, Isabelle ; Cox, David G. ; Norat, Teresa ; Riboli, Elio ; Clavel-Chapelon, Françoise. / Active and passive cigarette smoking and breast cancer risk : Results from the EPIC cohort. In: International Journal of Cancer. 2014 ; Vol. 134, No. 8. pp. 1871-1888.

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abstract = "Recent cohort studies suggest that increased breast cancer risks were associated with longer smoking duration, higher pack-years and a dose-response relationship with increasing pack-years of smoking between menarche and first full-term pregnancy (FFTP). Studies with comprehensive quantitative life-time measures of passive smoking suggest an association between passive smoking dose and breast cancer risk. We conducted a study within the European Prospective Investigation into Cancer and Nutrition to examine the association between passive and active smoking and risk of invasive breast cancer and possible effect modification by known breast cancer risk factors. Among the 322,988 women eligible for the study, 9,822 developed breast cancer (183,608 women with passive smoking information including 6,264 cases). When compared to women who never smoked and were not being exposed to passive smoking at home or work at the time of study registration, current, former and currently exposed passive smokers were at increased risk of breast cancer (hazard ratios (HR) [95% confidence interval (CI)] 1.16 [1.05-1.28], 1.14 [1.04-1.25] and 1.10 [1.01-1.20], respectively). Analyses exploring associations in different periods of life showed the most important increase in risk with pack-years from menarche to FFTP (1.73 [1.29-2.32] for every increase of 20 pack-years) while pack-years smoked after menopause were associated with a significant decrease in breast cancer risk (HR = 0.53, 95% CI: 0.34-0.82 for every increase of 20 pack-years). Our results provide an important replication, in the largest cohort to date, that smoking (passively or actively) increases breast cancer risk and that smoking between menarche and FFTP is particularly deleterious. What's new? The EPIC study is the largest cohort analysis on smoking and breast cancer to date. In this analysis of data from that study, the authors have confirmed that both active and passive exposure to cigarette smoke increases breast cancer risk. These results emphasize that it's important to distinguish between passive exposure and no exposure when analyzing the relationship between smoking and breast cancer. The authors also confirm that the most potent window of exposure for smoking and breast cancer risk is between menarche and first full term pregnancy.",

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author = "Laure Dossus and Boutron-Ruault, {Marie Christine} and Rudolf Kaaks and Gram, {Inger T.} and Alice Vilier and B{\'e}atrice Fervers and Jonas Manjer and Anne Tjonneland and Anja Olsen and Kim Overvad and Jenny Chang-Claude and Heiner Boeing and Annika Steffen and Antonia Trichopoulou and Pagona Lagiou and Maria Sarantopoulou and Domenico Palli and Franco Berrino and Rosario Tumino and Paolo Vineis and Amalia Mattiello and Bueno-De-Mesquita, {H. Bas} and {Van Duijnhoven}, {Franzel J B} and Bakker, {Marieke F.} and Peeters, {Petra Hm} and Elisabete Weiderpass and Eivind Bjerkaas and Tonje Braaten and Virginia Men{\'e}ndez and Antonio Agudo and Sanchez, {Maria Jose} and Pilar Amiano and Tormo, {Maria Jose} and Aurelio Barricarte and Salma Butt and Khaw, {Kay Tee} and Nicholas Wareham and Key, {Tim J.} and Travis, {Ruth C.} and Sabina Rinaldi and Valerie McCormack and Isabelle Romieu and Cox, {David G.} and Teresa Norat and Elio Riboli and Fran{\c c}oise Clavel-Chapelon",

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T1 - Active and passive cigarette smoking and breast cancer risk

T2 - Results from the EPIC cohort

AU - Dossus, Laure

AU - Boutron-Ruault, Marie Christine

AU - Kaaks, Rudolf

AU - Gram, Inger T.

AU - Vilier, Alice

AU - Fervers, Béatrice

AU - Manjer, Jonas

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Chang-Claude, Jenny

AU - Boeing, Heiner

AU - Steffen, Annika

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Sarantopoulou, Maria

AU - Palli, Domenico

AU - Berrino, Franco

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Mattiello, Amalia

AU - Bueno-De-Mesquita, H. Bas

AU - Van Duijnhoven, Franzel J B

AU - Bakker, Marieke F.

AU - Peeters, Petra Hm

AU - Weiderpass, Elisabete

AU - Bjerkaas, Eivind

AU - Braaten, Tonje

AU - Menéndez, Virginia

AU - Agudo, Antonio

AU - Sanchez, Maria Jose

AU - Amiano, Pilar

AU - Tormo, Maria Jose

AU - Barricarte, Aurelio

AU - Butt, Salma

AU - Khaw, Kay Tee

AU - Wareham, Nicholas

AU - Key, Tim J.

AU - Travis, Ruth C.

AU - Rinaldi, Sabina

AU - McCormack, Valerie

AU - Romieu, Isabelle

AU - Cox, David G.

AU - Norat, Teresa

AU - Riboli, Elio

AU - Clavel-Chapelon, Françoise

PY - 2014/4/15

Y1 - 2014/4/15

N2 - Recent cohort studies suggest that increased breast cancer risks were associated with longer smoking duration, higher pack-years and a dose-response relationship with increasing pack-years of smoking between menarche and first full-term pregnancy (FFTP). Studies with comprehensive quantitative life-time measures of passive smoking suggest an association between passive smoking dose and breast cancer risk. We conducted a study within the European Prospective Investigation into Cancer and Nutrition to examine the association between passive and active smoking and risk of invasive breast cancer and possible effect modification by known breast cancer risk factors. Among the 322,988 women eligible for the study, 9,822 developed breast cancer (183,608 women with passive smoking information including 6,264 cases). When compared to women who never smoked and were not being exposed to passive smoking at home or work at the time of study registration, current, former and currently exposed passive smokers were at increased risk of breast cancer (hazard ratios (HR) [95% confidence interval (CI)] 1.16 [1.05-1.28], 1.14 [1.04-1.25] and 1.10 [1.01-1.20], respectively). Analyses exploring associations in different periods of life showed the most important increase in risk with pack-years from menarche to FFTP (1.73 [1.29-2.32] for every increase of 20 pack-years) while pack-years smoked after menopause were associated with a significant decrease in breast cancer risk (HR = 0.53, 95% CI: 0.34-0.82 for every increase of 20 pack-years). Our results provide an important replication, in the largest cohort to date, that smoking (passively or actively) increases breast cancer risk and that smoking between menarche and FFTP is particularly deleterious. What's new? The EPIC study is the largest cohort analysis on smoking and breast cancer to date. In this analysis of data from that study, the authors have confirmed that both active and passive exposure to cigarette smoke increases breast cancer risk. These results emphasize that it's important to distinguish between passive exposure and no exposure when analyzing the relationship between smoking and breast cancer. The authors also confirm that the most potent window of exposure for smoking and breast cancer risk is between menarche and first full term pregnancy.

AB - Recent cohort studies suggest that increased breast cancer risks were associated with longer smoking duration, higher pack-years and a dose-response relationship with increasing pack-years of smoking between menarche and first full-term pregnancy (FFTP). Studies with comprehensive quantitative life-time measures of passive smoking suggest an association between passive smoking dose and breast cancer risk. We conducted a study within the European Prospective Investigation into Cancer and Nutrition to examine the association between passive and active smoking and risk of invasive breast cancer and possible effect modification by known breast cancer risk factors. Among the 322,988 women eligible for the study, 9,822 developed breast cancer (183,608 women with passive smoking information including 6,264 cases). When compared to women who never smoked and were not being exposed to passive smoking at home or work at the time of study registration, current, former and currently exposed passive smokers were at increased risk of breast cancer (hazard ratios (HR) [95% confidence interval (CI)] 1.16 [1.05-1.28], 1.14 [1.04-1.25] and 1.10 [1.01-1.20], respectively). Analyses exploring associations in different periods of life showed the most important increase in risk with pack-years from menarche to FFTP (1.73 [1.29-2.32] for every increase of 20 pack-years) while pack-years smoked after menopause were associated with a significant decrease in breast cancer risk (HR = 0.53, 95% CI: 0.34-0.82 for every increase of 20 pack-years). Our results provide an important replication, in the largest cohort to date, that smoking (passively or actively) increases breast cancer risk and that smoking between menarche and FFTP is particularly deleterious. What's new? The EPIC study is the largest cohort analysis on smoking and breast cancer to date. In this analysis of data from that study, the authors have confirmed that both active and passive exposure to cigarette smoke increases breast cancer risk. These results emphasize that it's important to distinguish between passive exposure and no exposure when analyzing the relationship between smoking and breast cancer. The authors also confirm that the most potent window of exposure for smoking and breast cancer risk is between menarche and first full term pregnancy.

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