TY - JOUR
T1 - Active HCV Replication but Not HCV or CMV Seropositive Status Is Associated with Incident and Prevalent Type 2 Diabetes in Persons Living with HIV
AU - De Luca, Andrea
AU - Lorenzini, Patrizia
AU - Castagna, Antonella
AU - Puoti, Massimo
AU - Gianotti, Nicola
AU - Castelli, Francesco
AU - Mastroianni, Claudio
AU - Maggiolo, Franco
AU - Antinori, Andrea
AU - Guaraldi, Giovanni
AU - Lichtner, Miriam
AU - Galli, M.
AU - Ippolito, G.
AU - Lazzarin, A.
AU - Perno, C. F.
AU - Girardi, E.
AU - Ammassari, A.
AU - Calcagno, A.
AU - Capobianchi, M. R.
AU - Cinque, P.
AU - Girardi, E.
AU - Gori, A.
AU - Nozza, S.
AU - Santoro, M. M.
AU - Zaccarelli, M.
AU - Galli, L.
AU - Rodano, A.
AU - Carletti, F.
AU - Carrara, S.
AU - Di Caro, A.
AU - Graziano, S.
AU - Prota, G.
AU - Quartu, S.
AU - Truffa, S.
AU - Donati, V.
AU - Viscoli, C.
AU - Castelli, A. P.
AU - Galli, M.
AU - Lazzarin, A.
AU - Gori, A.
AU - Magnani, G.
AU - Cristaudo, A.
AU - Cicalini, S.
AU - Nicastri, E.
AU - Acinapura, R.
AU - Capozzi, M.
AU - Libertone, R.
AU - Latini, A.
AU - Mura, M. S.
AU - Sciandra, M.
AU - the ICONA Foundation Study
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Objective: To analyze the association between chronic hepatitis C virus (HCV) and cytomegalovirus (CMV) infections with type 2 diabetes in HIV-infected patients. Methods: HIV-1-infected patients enrolled in ICONA, a prospective cohort study involving 42 tertiary care centers in Italy, were selected with the following characteristics: for the diabetes incidence analysis, all patients with available CMV IgG results (first available test = baseline) and without type 2 diabetes were followed until onset of type 2 diabetes, last available clinical follow-up, death or September 30, 2014, whichever occurred first; for the prevalence analysis, all ICONA patients were analyzed at their last follow-up visit. Main outcome measures were the new onset of type 2 diabetes (incidence analysis) and the prevalence of type 2 diabetes at last follow-up. Results: During 38,062 person-years of follow-up (PYFU) in 6505 individuals, we observed 140 cases of incident type 2 diabetes (Incidence rate 3.7, 95% CI: 3.1 to 4.3, per 1000 PYFU). In a multivariable Poisson regression model, HCV-antibody (Ab)+/HCV RNA+ patients [adjusted relative rate versus HCV-Ab negative 1.73 (95% CI: 1.08 to 2.78)] but not HCV Ab+RNA- or CMV IgG+ patients, had a higher risk of diabetes. Among 12,001 patients, 306 (2.5%) prevalent cases of type 2 diabetes were detected. HCV Ab+RNA+ status was independently associated with prevalent diabetes (adjusted Odds Ratio vs HCV Ab- 2.49; 95% CI: 1.08 to 5.74), whereas HCV-Ab+/HCV RNA- and CMV IgG+ status were not. Conclusion: In HIV-infected individuals, active HCV replication but not prior HCV exposure or latent CMV infection is associated with incident and prevalent type 2 diabetes.
AB - Objective: To analyze the association between chronic hepatitis C virus (HCV) and cytomegalovirus (CMV) infections with type 2 diabetes in HIV-infected patients. Methods: HIV-1-infected patients enrolled in ICONA, a prospective cohort study involving 42 tertiary care centers in Italy, were selected with the following characteristics: for the diabetes incidence analysis, all patients with available CMV IgG results (first available test = baseline) and without type 2 diabetes were followed until onset of type 2 diabetes, last available clinical follow-up, death or September 30, 2014, whichever occurred first; for the prevalence analysis, all ICONA patients were analyzed at their last follow-up visit. Main outcome measures were the new onset of type 2 diabetes (incidence analysis) and the prevalence of type 2 diabetes at last follow-up. Results: During 38,062 person-years of follow-up (PYFU) in 6505 individuals, we observed 140 cases of incident type 2 diabetes (Incidence rate 3.7, 95% CI: 3.1 to 4.3, per 1000 PYFU). In a multivariable Poisson regression model, HCV-antibody (Ab)+/HCV RNA+ patients [adjusted relative rate versus HCV-Ab negative 1.73 (95% CI: 1.08 to 2.78)] but not HCV Ab+RNA- or CMV IgG+ patients, had a higher risk of diabetes. Among 12,001 patients, 306 (2.5%) prevalent cases of type 2 diabetes were detected. HCV Ab+RNA+ status was independently associated with prevalent diabetes (adjusted Odds Ratio vs HCV Ab- 2.49; 95% CI: 1.08 to 5.74), whereas HCV-Ab+/HCV RNA- and CMV IgG+ status were not. Conclusion: In HIV-infected individuals, active HCV replication but not prior HCV exposure or latent CMV infection is associated with incident and prevalent type 2 diabetes.
KW - CMV
KW - diabetes
KW - HCV
KW - HCV-RNA
KW - HIV-1
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U2 - 10.1097/QAI.0000000000001443
DO - 10.1097/QAI.0000000000001443
M3 - Article
C2 - 28653972
AN - SCOPUS:85021858889
VL - 75
SP - 465
EP - 471
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
SN - 1525-4135
IS - 4
ER -