Active Sequences Collection (ASC) database: A new tool to assign functions to protein sequences

Angelo M. Facchiano, Antonio Facchiano, Francesco Facchiano

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Active Sequences Collection (ASC) is a collection of amino acid sequences, with an unique feature: only short sequences are collected, with a demonstrated biological activity. The current version of ASC consists of three sections: DORRS, a collection of active RGD-containing peptides; TRANSIT, a collection of protein regions active as substrates of transglutaminase enzyme (TGase), and BAC, a collection of short peptides with demonstrated biological activity. Literature references for each entry are reported, as well as cross references to other databases, when available. The current version of ASC includes more than 800 different entries. The main scope of this collection is to offer a new tool to investigate the structural features of protein active sites, additionally to similarity searches against large protein databases or searching for known functional patterns. ASC database is available at the web address http://crisceb.unina2.it/ASC/ which also offers a dedicated query interface to compare user-defined protein sequences with the database, as well as an updating interface to allow contribution of new referenced active sequences.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalNucleic Acids Research
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

Fingerprint

Protein Databases
Databases
Transglutaminases
Amino Acid Sequence
Catalytic Domain
Proteins
Peptides
Enzymes
arginyl-glycyl-aspartic acid

ASJC Scopus subject areas

  • Genetics

Cite this

Active Sequences Collection (ASC) database : A new tool to assign functions to protein sequences. / Facchiano, Angelo M.; Facchiano, Antonio; Facchiano, Francesco.

In: Nucleic Acids Research, Vol. 31, No. 1, 01.01.2003, p. 379-382.

Research output: Contribution to journalArticle

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