Active surveillance for low-risk prostate cancer worldwide: The PRIAS study

Meelan Bul, Xiaoye Zhu, Riccardo Valdagni, Tom Pickles, Yoshiyuki Kakehi, Antti Rannikko, Anders Bjartell, Deric K. Van Der Schoot, Erik B. Cornel, Giario N. Conti, Egbert R. Boevé, Frédéric Staerman, Jenneke J. Vis-Maters, Henk Vergunst, Joris J. Jaspars, Petra Strölin, Erik Van Muilekom, Fritz H. Schröder, Chris H. Bangma, Monique J. Roobol

Research output: Contribution to journalArticle

Abstract

Background: Overdiagnosis and subsequent overtreatment are important side effects of screening for, and early detection of, prostate cancer (PCa). Active surveillance (AS) is of growing interest as an alternative to radical treatment of low-risk PCa. Objective: To update our experience in the largest worldwide prospective AS cohort. Design, setting, and participants: Eligible patients had clinical stage T1/T2 PCa, prostate-specific antigen (PSA) ≤10 ng/ml, PSA density 6 at repeat biopsy. Recommendation for treatment was triggered in case of PSA doubling time

Original languageEnglish
Pages (from-to)597-603
Number of pages7
JournalEuropean Urology
Volume63
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Active surveillance
  • Prognostic factors
  • Prostate-specific antigen
  • Prostatic neoplasms
  • Reclassification

ASJC Scopus subject areas

  • Urology

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  • Cite this

    Bul, M., Zhu, X., Valdagni, R., Pickles, T., Kakehi, Y., Rannikko, A., Bjartell, A., Van Der Schoot, D. K., Cornel, E. B., Conti, G. N., Boevé, E. R., Staerman, F., Vis-Maters, J. J., Vergunst, H., Jaspars, J. J., Strölin, P., Van Muilekom, E., Schröder, F. H., Bangma, C. H., & Roobol, M. J. (2013). Active surveillance for low-risk prostate cancer worldwide: The PRIAS study. European Urology, 63(4), 597-603. https://doi.org/10.1016/j.eururo.2012.11.005