Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy

Pasquale Florio, Alessandro Frigiola, Raffaele Battista, Ali El Hadi Abdalla, Diego Gazzolo, Letizia Galleri, Serena Pinzauti, Raul Abella, Giovanni Li Volti, Mirella Strambi, Felice Petraglia

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Activin-A is a protein over-expressed and secreted by the brain after neuronal destruction. We evaluated whether serum activin-A increases in asphyxiated full-term newborns (AFTNs) at risk of hypoxic-ischemicencephalopathy (HIE). 105 consecutive infants (35 affected by perinatal asphyxia due to acute fetal distress; 70 healthy gestational-age matched newborns) underwent cranial assessment and neurologic examination at 12, 24 and 72 hours after birth and, on discharge from the hospital and; activin-A and monitoring laboratory variables assessment at birth. According to the occurrence of HIE within 7-days after birth, AFTNs were subdivided in Group A (n= 20; no/mild HIE with good prognosis) and Group B (n= 15; moderate/severe HIE with a greater risk of neurological handicap). Activin-A was significantly (P less than 0.0001) higher in Groups A and B than controls and highest (P less than 0.001) in Group B. At 0.66 ng/L activin-A achieved a sensitivity of 93.33% and a specificity of 96.63%, respectively, as HIE diagnostic test. These findings show that activin A increased in AFTNs with HIE before the appearance of related signs.

Original languageEnglish
Pages (from-to)36-42
Number of pages7
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number1
Publication statusPublished - Jan 1 2010

Fingerprint

Brain Hypoxia-Ischemia
Newborn Infant
Parturition
Term Birth
Fetal Distress
Asphyxia
Neurologic Examination
Routine Diagnostic Tests
Gestational Age
activin A
Brain
Monitoring
Serum
Proteins

Keywords

  • Asphyxia
  • Brain damage
  • Hypoxia
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Florio, P., Frigiola, A., Battista, R., El Hadi Abdalla, A., Gazzolo, D., Galleri, L., ... Petraglia, F. (2010). Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. Frontiers in Bioscience - Elite, 2 E(1), 36-42.

Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. / Florio, Pasquale; Frigiola, Alessandro; Battista, Raffaele; El Hadi Abdalla, Ali; Gazzolo, Diego; Galleri, Letizia; Pinzauti, Serena; Abella, Raul; Li Volti, Giovanni; Strambi, Mirella; Petraglia, Felice.

In: Frontiers in Bioscience - Elite, Vol. 2 E, No. 1, 01.01.2010, p. 36-42.

Research output: Contribution to journalArticle

Florio, P, Frigiola, A, Battista, R, El Hadi Abdalla, A, Gazzolo, D, Galleri, L, Pinzauti, S, Abella, R, Li Volti, G, Strambi, M & Petraglia, F 2010, 'Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy', Frontiers in Bioscience - Elite, vol. 2 E, no. 1, pp. 36-42.
Florio P, Frigiola A, Battista R, El Hadi Abdalla A, Gazzolo D, Galleri L et al. Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. Frontiers in Bioscience - Elite. 2010 Jan 1;2 E(1):36-42.
Florio, Pasquale ; Frigiola, Alessandro ; Battista, Raffaele ; El Hadi Abdalla, Ali ; Gazzolo, Diego ; Galleri, Letizia ; Pinzauti, Serena ; Abella, Raul ; Li Volti, Giovanni ; Strambi, Mirella ; Petraglia, Felice. / Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. In: Frontiers in Bioscience - Elite. 2010 ; Vol. 2 E, No. 1. pp. 36-42.
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