Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy

Pasquale Florio, Alessandro Frigiola, Raffaele Battista, Ali El Hadi Abdalla, Diego Gazzolo, Letizia Galleri, Serena Pinzauti, Raul Abella, Giovanni Li Volti, Mirella Strambi, Felice Petraglia

Research output: Contribution to journalArticle

Abstract

Activin-A is a protein over-expressed and secreted by the brain after neuronal destruction. We evaluated whether serum activin-A increases in asphyxiated full-term newborns (AFTNs) at risk of hypoxic-ischemicencephalopathy (HIE). 105 consecutive infants (35 affected by perinatal asphyxia due to acute fetal distress; 70 healthy gestational-age matched newborns) underwent cranial assessment and neurologic examination at 12, 24 and 72 hours after birth and, on discharge from the hospital and; activin-A and monitoring laboratory variables assessment at birth. According to the occurrence of HIE within 7-days after birth, AFTNs were subdivided in Group A (n= 20; no/mild HIE with good prognosis) and Group B (n= 15; moderate/severe HIE with a greater risk of neurological handicap). Activin-A was significantly (P less than 0.0001) higher in Groups A and B than controls and highest (P less than 0.001) in Group B. At 0.66 ng/L activin-A achieved a sensitivity of 93.33% and a specificity of 96.63%, respectively, as HIE diagnostic test. These findings show that activin A increased in AFTNs with HIE before the appearance of related signs.

Original languageEnglish
Pages (from-to)36-42
Number of pages7
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number1
Publication statusPublished - Jan 1 2010

Keywords

  • Asphyxia
  • Brain damage
  • Hypoxia
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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    Florio, P., Frigiola, A., Battista, R., El Hadi Abdalla, A., Gazzolo, D., Galleri, L., Pinzauti, S., Abella, R., Li Volti, G., Strambi, M., & Petraglia, F. (2010). Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. Frontiers in Bioscience - Elite, 2 E(1), 36-42.