Activity and safety of metronomic cyclophosphamide in the modern era of metastatic castration-resistant prostate cancer

Orazio Caffo; Gaetano Facchini; Elisa Biasco; Francesco Ferraù; Franco Morelli; Maddalena Donini; Consuelo Buttigliero; Nicola Calvani; Annalisa Guida; Vincenzo Emanuele Chiuri; Umberto Basso; Claudia Mucciarini; Vincenza Conteduca; Sabrina Rossetti; Antonello Veccia; Francesca Maines; Stefania Kinspergher; Ugo De Giorgi

doi:10.2217/fon-2018-0715

Activity and safety of metronomic cyclophosphamide in the modern era of metastatic castration-resistant prostate cancer

Orazio Caffo, Gaetano Facchini, Elisa Biasco, Francesco Ferraù, Franco Morelli, Maddalena Donini, Consuelo Buttigliero, Nicola Calvani, Annalisa Guida, Vincenzo Emanuele Chiuri, Umberto Basso, Claudia Mucciarini, Vincenza Conteduca, Sabrina Rossetti, Antonello Veccia, Francesca Maines, Stefania Kinspergher, Ugo De Giorgi

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article

Abstract

AIM: To evaluate activity of metronomic cyclophosphamide (mCTX) in heavily pretreated metastatic castration-resistant prostate cancer (mCRPC) patients.

PATIENTS & METHODS: We retrospectively evaluated a consecutive series of 74 mCRPC patients treated with at least one new agent after docetaxel failure, who received once daily oral mCTX treatment at a fixed dose of 50 mg.

RESULTS: The treatment was well tolerated. Sixteen percent of the patients experienced a major biochemical response. Median progression-free survival was 4.0 months, and median overall survival was 8.1 months.

CONCLUSIONS: In the modern context of mCRPC, mCTX may represent a valuable and inexpensive alternative to new agents, which have shown similar activity in heavily pretreated patients.

Original language	English
Journal	Future Oncology
DOIs	https://doi.org/10.2217/fon-2018-0715
Publication status	Published - Mar 19 2019

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Caffo, O., Facchini, G., Biasco, E., Ferraù, F., Morelli, F., Donini, M., Buttigliero, C., Calvani, N., Guida, A., Chiuri, V. E., Basso, U., Mucciarini, C., Conteduca, V., Rossetti, S., Veccia, A., Maines, F., Kinspergher, S., & De Giorgi, U. (2019). Activity and safety of metronomic cyclophosphamide in the modern era of metastatic castration-resistant prostate cancer. Future Oncology. https://doi.org/10.2217/fon-2018-0715

Activity and safety of metronomic cyclophosphamide in the modern era of metastatic castration-resistant prostate cancer. / Caffo, Orazio; Facchini, Gaetano; Biasco, Elisa; Ferraù, Francesco; Morelli, Franco; Donini, Maddalena; Buttigliero, Consuelo; Calvani, Nicola; Guida, Annalisa; Chiuri, Vincenzo Emanuele; Basso, Umberto; Mucciarini, Claudia; Conteduca, Vincenza; Rossetti, Sabrina; Veccia, Antonello; Maines, Francesca; Kinspergher, Stefania; De Giorgi, Ugo.

In: Future Oncology, 19.03.2019.

Research output: Contribution to journal › Article

Caffo, O, Facchini, G, Biasco, E, Ferraù, F, Morelli, F, Donini, M, Buttigliero, C, Calvani, N, Guida, A, Chiuri, VE, Basso, U, Mucciarini, C, Conteduca, V, Rossetti, S, Veccia, A, Maines, F, Kinspergher, S & De Giorgi, U 2019, 'Activity and safety of metronomic cyclophosphamide in the modern era of metastatic castration-resistant prostate cancer', Future Oncology. https://doi.org/10.2217/fon-2018-0715

Caffo, Orazio ; Facchini, Gaetano ; Biasco, Elisa ; Ferraù, Francesco ; Morelli, Franco ; Donini, Maddalena ; Buttigliero, Consuelo ; Calvani, Nicola ; Guida, Annalisa ; Chiuri, Vincenzo Emanuele ; Basso, Umberto ; Mucciarini, Claudia ; Conteduca, Vincenza ; Rossetti, Sabrina ; Veccia, Antonello ; Maines, Francesca ; Kinspergher, Stefania ; De Giorgi, Ugo. / Activity and safety of metronomic cyclophosphamide in the modern era of metastatic castration-resistant prostate cancer. In: Future Oncology. 2019.

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abstract = "AIM: To evaluate activity of metronomic cyclophosphamide (mCTX) in heavily pretreated metastatic castration-resistant prostate cancer (mCRPC) patients.PATIENTS & METHODS: We retrospectively evaluated a consecutive series of 74 mCRPC patients treated with at least one new agent after docetaxel failure, who received once daily oral mCTX treatment at a fixed dose of 50 mg.RESULTS: The treatment was well tolerated. Sixteen percent of the patients experienced a major biochemical response. Median progression-free survival was 4.0 months, and median overall survival was 8.1 months.CONCLUSIONS: In the modern context of mCRPC, mCTX may represent a valuable and inexpensive alternative to new agents, which have shown similar activity in heavily pretreated patients.",

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AU - Caffo, Orazio

AU - Facchini, Gaetano

AU - Biasco, Elisa

AU - Ferraù, Francesco

AU - Morelli, Franco

AU - Donini, Maddalena

AU - Buttigliero, Consuelo

AU - Calvani, Nicola

AU - Guida, Annalisa

AU - Chiuri, Vincenzo Emanuele

AU - Basso, Umberto

AU - Mucciarini, Claudia

AU - Conteduca, Vincenza

AU - Rossetti, Sabrina

AU - Veccia, Antonello

AU - Maines, Francesca

AU - Kinspergher, Stefania

AU - De Giorgi, Ugo

PY - 2019/3/19

Y1 - 2019/3/19

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AB - AIM: To evaluate activity of metronomic cyclophosphamide (mCTX) in heavily pretreated metastatic castration-resistant prostate cancer (mCRPC) patients.PATIENTS & METHODS: We retrospectively evaluated a consecutive series of 74 mCRPC patients treated with at least one new agent after docetaxel failure, who received once daily oral mCTX treatment at a fixed dose of 50 mg.RESULTS: The treatment was well tolerated. Sixteen percent of the patients experienced a major biochemical response. Median progression-free survival was 4.0 months, and median overall survival was 8.1 months.CONCLUSIONS: In the modern context of mCRPC, mCTX may represent a valuable and inexpensive alternative to new agents, which have shown similar activity in heavily pretreated patients.

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DO - 10.2217/fon-2018-0715

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