Abstract
The available estimate of the energy expended for signaling in rat neocortex is refined to examine the separate contribution of spiking and synaptic activity as a function of average neuronal firing rate. By taking into account a phenomenological model of short-term synaptic plasticity, we show that the transition from low to high cortical activity is accompanied by a substantial increase in relative energy consumed by action potentials vs. synaptic potentials. This consideration might be important for a deeper understanding of how information is represented in the cortex and which metabolic pathways are upregulated to sustain cortical activity.
Original language | English |
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Pages (from-to) | 2094-2102 |
Number of pages | 9 |
Journal | Journal of Neuroscience Research |
Volume | 90 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2012 |
Keywords
- Neurometabolic coupling
- Short-term synaptic plasticity
- Spiking activity
- Synaptic activity
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience