Abstract
The available estimate of the energy expended for signaling in rat neocortex is refined to examine the separate contribution of spiking and synaptic activity as a function of average neuronal firing rate. By taking into account a phenomenological model of short-term synaptic plasticity, we show that the transition from low to high cortical activity is accompanied by a substantial increase in relative energy consumed by action potentials vs. synaptic potentials. This consideration might be important for a deeper understanding of how information is represented in the cortex and which metabolic pathways are upregulated to sustain cortical activity.
| Original language | English |
|---|---|
| Pages (from-to) | 2094-2102 |
| Number of pages | 9 |
| Journal | Journal of Neuroscience Research |
| Volume | 90 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2012 |
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Keywords
- Neurometabolic coupling
- Short-term synaptic plasticity
- Spiking activity
- Synaptic activity
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
Cite this
Activity-dependent energy budget for neocortical signaling : Effect of short-term synaptic plasticity on the energy expended by spiking and synaptic activity. / Dinuzzo, Mauro; Giove, Federico.
In: Journal of Neuroscience Research, Vol. 90, No. 11, 11.2012, p. 2094-2102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Activity-dependent energy budget for neocortical signaling
T2 - Effect of short-term synaptic plasticity on the energy expended by spiking and synaptic activity
AU - Dinuzzo, Mauro
AU - Giove, Federico
PY - 2012/11
Y1 - 2012/11
N2 - The available estimate of the energy expended for signaling in rat neocortex is refined to examine the separate contribution of spiking and synaptic activity as a function of average neuronal firing rate. By taking into account a phenomenological model of short-term synaptic plasticity, we show that the transition from low to high cortical activity is accompanied by a substantial increase in relative energy consumed by action potentials vs. synaptic potentials. This consideration might be important for a deeper understanding of how information is represented in the cortex and which metabolic pathways are upregulated to sustain cortical activity.
AB - The available estimate of the energy expended for signaling in rat neocortex is refined to examine the separate contribution of spiking and synaptic activity as a function of average neuronal firing rate. By taking into account a phenomenological model of short-term synaptic plasticity, we show that the transition from low to high cortical activity is accompanied by a substantial increase in relative energy consumed by action potentials vs. synaptic potentials. This consideration might be important for a deeper understanding of how information is represented in the cortex and which metabolic pathways are upregulated to sustain cortical activity.
KW - Neurometabolic coupling
KW - Short-term synaptic plasticity
KW - Spiking activity
KW - Synaptic activity
UR - http://www.scopus.com/inward/record.url?scp=84866050839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866050839&partnerID=8YFLogxK
U2 - 10.1002/jnr.23098
DO - 10.1002/jnr.23098
M3 - Article
C2 - 22740502
AN - SCOPUS:84866050839
VL - 90
SP - 2094
EP - 2102
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
SN - 0360-4012
IS - 11
ER -