Activity-dependent energy budget for neocortical signaling: Effect of short-term synaptic plasticity on the energy expended by spiking and synaptic activity

Mauro Dinuzzo, Federico Giove

Research output: Contribution to journalArticle

Abstract

The available estimate of the energy expended for signaling in rat neocortex is refined to examine the separate contribution of spiking and synaptic activity as a function of average neuronal firing rate. By taking into account a phenomenological model of short-term synaptic plasticity, we show that the transition from low to high cortical activity is accompanied by a substantial increase in relative energy consumed by action potentials vs. synaptic potentials. This consideration might be important for a deeper understanding of how information is represented in the cortex and which metabolic pathways are upregulated to sustain cortical activity.

Original languageEnglish
Pages (from-to)2094-2102
Number of pages9
JournalJournal of Neuroscience Research
Volume90
Issue number11
DOIs
Publication statusPublished - Nov 2012

    Fingerprint

Keywords

  • Neurometabolic coupling
  • Short-term synaptic plasticity
  • Spiking activity
  • Synaptic activity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this