Activity of 1-p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt in M 5076/73A ovarian reticular cell sarcoma of the mouse

T. Colombo, S. Garattini, L. Lassiani, M. D'Incalci

Research output: Contribution to journalArticle

Abstract

1-p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt (DM-COOK) as tested on M 5076/73A (M5) mouse sarcoma at a dose of 40 or 50 mg/kg/day (Days 6-14) after im transplant of 7 x 105 cells, with or without surgical removal of the primary tumor on Dat 14. Treatment at either dose level resulted in reduction of the primary tumor weight to around 50% of that in the controls, and striking antimetastatic effects were observed. When a dose of 40 or 50 mg/kg of DM-COOK was followed by surgery, there were 14% and 40% long-term survivors, respectively, but the higher dose caused about 30% toxic deaths. After iv injection of 103 or 105 M5 tumor cells, no artificial metastases appeared in DM-COOK-treated mice, whereas all control animals had metastatic involvement in the liver, spleen, ovaries, and kidneys.

Original languageEnglish
Pages (from-to)1945-1948
Number of pages4
JournalCancer Treatment Reports
Volume66
Issue number11
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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