1-p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt (DM-COOK) as tested on M 5076/73A (M5) mouse sarcoma at a dose of 40 or 50 mg/kg/day (Days 6-14) after im transplant of 7 x 105 cells, with or without surgical removal of the primary tumor on Dat 14. Treatment at either dose level resulted in reduction of the primary tumor weight to around 50% of that in the controls, and striking antimetastatic effects were observed. When a dose of 40 or 50 mg/kg of DM-COOK was followed by surgery, there were 14% and 40% long-term survivors, respectively, but the higher dose caused about 30% toxic deaths. After iv injection of 103 or 105 M5 tumor cells, no artificial metastases appeared in DM-COOK-treated mice, whereas all control animals had metastatic involvement in the liver, spleen, ovaries, and kidneys.
|Number of pages||4|
|Journal||Cancer Treatment Reports|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Cancer Research