TY - JOUR
T1 - Activity of 4'-epi-doxorubicin on normal hematopoietic precursor cells in mice
AU - Sobrero, A.
AU - Muzzulini, C.
AU - D'Amore, F.
AU - Bogliolo, G.
AU - Massa, G.
AU - Ghio, R.
AU - Pannacciulli, I.
PY - 1982
Y1 - 1982
N2 - The effects of 4'-epi-doxorubicin (4'-epi-DX) on survival of in situ murine bone marrow hematopoietic precursor cells (HPC) were studied. The drug was given to (C57BL x C3H)F 1 mice in increasing single doses, in repeated administrations (three times in 5 days), or for a long period (twice a week for 10 weeks). Survival of colony-forming units (CFU(s), spleen; CFU(c), culture; and CFU(e), erythroid) was assayed by in vivo and in vitro methods; dose survival curves were exponential. It appears that single doses of 4'-epi-DX have a greater impact on murine HPC than single doses of the parent compound. Following repeated administrations pluripotential stem cells recover better after the derivative than after its parent drug. During prolonged treatment, the bone marrow content of committed progenitors is depleted to a lesser extent in the animals treated with 4'-epi-DX than in those receiving DX. It is, however, possible that, following the same prolonged treatment, this difference is minimal. In conclusion, these experimental data seem to indicate that 4'-epi-DX has lower toxicity in murine HPC than DX and that this is evident mainly after repeated administration for a short period of time.
AB - The effects of 4'-epi-doxorubicin (4'-epi-DX) on survival of in situ murine bone marrow hematopoietic precursor cells (HPC) were studied. The drug was given to (C57BL x C3H)F 1 mice in increasing single doses, in repeated administrations (three times in 5 days), or for a long period (twice a week for 10 weeks). Survival of colony-forming units (CFU(s), spleen; CFU(c), culture; and CFU(e), erythroid) was assayed by in vivo and in vitro methods; dose survival curves were exponential. It appears that single doses of 4'-epi-DX have a greater impact on murine HPC than single doses of the parent compound. Following repeated administrations pluripotential stem cells recover better after the derivative than after its parent drug. During prolonged treatment, the bone marrow content of committed progenitors is depleted to a lesser extent in the animals treated with 4'-epi-DX than in those receiving DX. It is, however, possible that, following the same prolonged treatment, this difference is minimal. In conclusion, these experimental data seem to indicate that 4'-epi-DX has lower toxicity in murine HPC than DX and that this is evident mainly after repeated administration for a short period of time.
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M3 - Article
C2 - 6958365
AN - SCOPUS:0020407136
VL - 66
SP - 2061
EP - 2070
JO - Cancer Treatment Reports
JF - Cancer Treatment Reports
SN - 0361-5960
IS - 12
ER -