Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions

G. Colella, M. Pennati, A. Bearzatto, R. Leone, D. Colangelo, C. Manzotti, M. G. Daidone, N. Zaffaroni

Research output: Contribution to journalArticlepeer-review

Abstract

A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.

Original languageEnglish
Pages (from-to)1387-1390
Number of pages4
JournalBritish Journal of Cancer
Volume84
Issue number10
DOIs
Publication statusPublished - May 18 2001

Keywords

  • BBR 3464
  • Cisplatin
  • DNA repair
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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