Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions

G. Colella; M. Pennati; A. Bearzatto; R. Leone; D. Colangelo; C. Manzotti; M. G. Daidone; N. Zaffaroni

doi:10.1054/bjoc.2001.1751

Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions

G. Colella, M. Pennati, A. Bearzatto, R. Leone, D. Colangelo, C. Manzotti, M. G. Daidone, N. Zaffaroni

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.

Original language	English
Pages (from-to)	1387-1390
Number of pages	4
Journal	British Journal of Cancer
Volume	84
Issue number	10
DOIs	https://doi.org/10.1054/bjoc.2001.1751
Publication status	Published - May 18 2001

Keywords

BBR 3464
Cisplatin
DNA repair
Ovarian cancer

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1054/bjoc.2001.1751

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Colella, G., Pennati, M., Bearzatto, A., Leone, R., Colangelo, D., Manzotti, C., Daidone, M. G., & Zaffaroni, N. (2001). Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions. British Journal of Cancer, 84(10), 1387-1390. https://doi.org/10.1054/bjoc.2001.1751

Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin : Cytotoxicity and induction and gene-specific repair of DNA lesions. / Colella, G.; Pennati, M.; Bearzatto, A.; Leone, R.; Colangelo, D.; Manzotti, C.; Daidone, M. G.; Zaffaroni, N.

In: British Journal of Cancer, Vol. 84, No. 10, 18.05.2001, p. 1387-1390.

Research output: Contribution to journal › Article › peer-review

Colella, G, Pennati, M, Bearzatto, A, Leone, R, Colangelo, D, Manzotti, C, Daidone, MG & Zaffaroni, N 2001, 'Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions', British Journal of Cancer, vol. 84, no. 10, pp. 1387-1390. https://doi.org/10.1054/bjoc.2001.1751

Colella, G. ; Pennati, M. ; Bearzatto, A. ; Leone, R. ; Colangelo, D. ; Manzotti, C. ; Daidone, M. G. ; Zaffaroni, N. / Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin : Cytotoxicity and induction and gene-specific repair of DNA lesions. In: British Journal of Cancer. 2001 ; Vol. 84, No. 10. pp. 1387-1390.

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