Abstract
A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.
Original language | English |
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Pages (from-to) | 1387-1390 |
Number of pages | 4 |
Journal | British Journal of Cancer |
Volume | 84 |
Issue number | 10 |
DOIs | |
Publication status | Published - May 18 2001 |
Keywords
- BBR 3464
- Cisplatin
- DNA repair
- Ovarian cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology