Activity of caffeic acid derivatives against Candida albicans biofilm

Daniela De Vita, Laura Friggeri, Felicia Diodata D'Auria, Fabiana Pandolfi, Francesco Piccoli, Simona Panella, Anna Teresa Palamara, Giovanna Simonetti, Luigi Scipione, Roberto Di Santo, Roberta Costi, Silvano Tortorella

Research output: Contribution to journalArticlepeer-review


The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16 μg/mL, respectively, and in the early stage of biofilm formation (4 h) with MIC 50 values of 64, 32 and 64 μg/mL, respectively. These esters result also more active than fluconazole on mature biofilm (24 h), especially 8 and 10 with MIC50 values of 64 μg/mL.

Original languageEnglish
Pages (from-to)1502-1505
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number6
Publication statusPublished - Mar 15 2014


  • Anti-biofilm agents
  • Biofilm formation
  • Caffeic acid
  • Candida albicans biofilm

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science


Dive into the research topics of 'Activity of caffeic acid derivatives against Candida albicans biofilm'. Together they form a unique fingerprint.

Cite this