TY - JOUR
T1 - Activity of classical and alternative pathways of complement in preterm and small for gestational age infants
AU - Notarangelo, Luigi D.
AU - Chirico, Gaetano
AU - Chiara, Alberto
AU - Colombo, Angelo
AU - Rondini, Giorgio
AU - Plebani, Alessandro
AU - Martini, Alberto
AU - Ugazio, Alberto G.
PY - 1984
Y1 - 1984
N2 - mplement activity was compared in 50 low birth weight infants divided into appropriate and small for gestational age groups; the influence of birth weight and gestational age on complement development was also investigated. CH50 and kinetics (tH50) of both classical and alternative pathway activity of complement, C3, and Factor B levels were significantly higher in small for gestational age infants (classical pathway CH50, 630 HU/ml ± 184 SD; CP tHjo, 77 min ± 47; aternative pathway CH50, 44.8 HU/ml ±11.3; AP tH50, 56 min ± 43; C3, 73.98 mg/dl ± 12.68; and Factor B, 13.17 mg/dl ± 3.67) than in weight-matched appropriate for gestational age infants (CP CH50, 523 HU/ml ± 152; CP tH50, 105 min ± 49; AP CH5o, 38.8 HU/ml ± 13; AP tHs50, 90 min ± 53; C3, 58.14 mg/dl + 9.43; and Factor B, 9.32 mg/dl ± 1.73). Complement values were lower in low birth weight infants than in adult controls (P
AB - mplement activity was compared in 50 low birth weight infants divided into appropriate and small for gestational age groups; the influence of birth weight and gestational age on complement development was also investigated. CH50 and kinetics (tH50) of both classical and alternative pathway activity of complement, C3, and Factor B levels were significantly higher in small for gestational age infants (classical pathway CH50, 630 HU/ml ± 184 SD; CP tHjo, 77 min ± 47; aternative pathway CH50, 44.8 HU/ml ±11.3; AP tH50, 56 min ± 43; C3, 73.98 mg/dl ± 12.68; and Factor B, 13.17 mg/dl ± 3.67) than in weight-matched appropriate for gestational age infants (CP CH50, 523 HU/ml ± 152; CP tH50, 105 min ± 49; AP CH5o, 38.8 HU/ml ± 13; AP tHs50, 90 min ± 53; C3, 58.14 mg/dl + 9.43; and Factor B, 9.32 mg/dl ± 1.73). Complement values were lower in low birth weight infants than in adult controls (P
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M3 - Article
C2 - 6563517
AN - SCOPUS:0021364557
VL - 18
SP - 281
EP - 285
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 3
ER -