Activity of cyclophosphamide and 1-methylnitrosourea on Ehrlich carcinoma transplanted in different sites. Correlation between drug level and tumor inhibition

A. Bossi, T. Colombo, M. G. Donelli, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Previous findings show that experimental tumors of the mouse, such as Ehrlich carcinoma and Sarcoma 180, transplanted in different sites, elicit a different sensitivity to the same drug according to the site of tumor implantation. Cyclophosphamide is highly active on intraperitoneal or subcutaneous tumors, but is ineffective on intracerebral tumors. However, the opposite is true for drugs such as nitroso-derivatives, which are active only on intracerebral tumors. The studies presented in this report were performed in order to elucidate whether different concentrations of drugs at the three tumor sites are related to the different antitumoral effects. It was found that measurements of blood and tissue concentrations explain fairly well the different activities of the drugs being tested.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalBiochemical Pharmacology
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 1 1975

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Activity of cyclophosphamide and 1-methylnitrosourea on Ehrlich carcinoma transplanted in different sites. Correlation between drug level and tumor inhibition'. Together they form a unique fingerprint.

Cite this