Activity of cytokine-induced killer cells against bone and soft tissue sarcoma

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1 Citation (Scopus)

Abstract

Cytokine-induced killer (CIK) cells are T lymphocytes expanded ex vivo that are endowed with MHC-independent tumoricidal activity. We have recently demonstrated, in a preclinical setting, that CIK cells are active against autologous bone and soft tissue sarcomas. In particular, CIK cells killed a putative sarcoma stem cell population that may underlie disease relapse and chemoresistance.

Original languageEnglish
Article numbere28269
JournalOncoImmunology
Volume3
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Cytokine-Induced Killer Cells
Sarcoma
Bone and Bones
Stem Cells
T-Lymphocytes
Recurrence
Population

Keywords

  • Adoptive immunotherapy
  • Cancer stem cells
  • CIK cells
  • Sarcomas
  • Solid tumors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

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title = "Activity of cytokine-induced killer cells against bone and soft tissue sarcoma",
abstract = "Cytokine-induced killer (CIK) cells are T lymphocytes expanded ex vivo that are endowed with MHC-independent tumoricidal activity. We have recently demonstrated, in a preclinical setting, that CIK cells are active against autologous bone and soft tissue sarcomas. In particular, CIK cells killed a putative sarcoma stem cell population that may underlie disease relapse and chemoresistance.",
keywords = "Adoptive immunotherapy, Cancer stem cells, CIK cells, Sarcomas, Solid tumors",
author = "Dario Sangiolo and Giulia Mesiano and Loretta Gammaitoni and Massimo Aglietta and Giovanni Grignani",
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AU - Mesiano, Giulia

AU - Gammaitoni, Loretta

AU - Aglietta, Massimo

AU - Grignani, Giovanni

PY - 2014

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AB - Cytokine-induced killer (CIK) cells are T lymphocytes expanded ex vivo that are endowed with MHC-independent tumoricidal activity. We have recently demonstrated, in a preclinical setting, that CIK cells are active against autologous bone and soft tissue sarcomas. In particular, CIK cells killed a putative sarcoma stem cell population that may underlie disease relapse and chemoresistance.

KW - Adoptive immunotherapy

KW - Cancer stem cells

KW - CIK cells

KW - Sarcomas

KW - Solid tumors

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