Activity of GH/IGF-I axis in trauma and septic patients during artificial nutrition: Different behavior patterns?

G. Pittoni, G. Gallioli, M. Zanello, L. Gianotti, M. F. Boghen, S. Colombo, F. Broglio, C. Santoro, G. Davià, M. G. Papini, S. Destefanis, F. Minuto, C. Miola, Ezio Ghigo

Research output: Contribution to journalArticle

Abstract

The aim of this study was to compare several parameters of GH/IGF-I axis activity in septic and trauma patients during Intensive Care Unit (ICU) stay. To this goal, 13 patients with sepsis (SEP) and 16 with trauma (TRA) were studied. Thirty-three adult subjects (AS) were studied as controls. Serum IGF-I and -II, IGFBP-1, -2 and -3, GH and GHBP levels were studied on day 1, 3, 5 and 7 after ICU admission, during comparable artificial nutrition in SEP and TRA and basally in AS. In 5 patients with SEP and 6 with TRA, the GH response to GHRH was evaluated on day 3. On ICU day 1, IGF-I and -II and IGFBP-3 in SEP were lower (p

Original languageEnglish
Pages (from-to)214-223
Number of pages10
JournalJournal of Endocrinological Investigation
Volume25
Issue number3
Publication statusPublished - 2002

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Keywords

  • Critical illness
  • GH
  • IGFBPs
  • IGFs
  • Nutrition
  • Sepsis
  • Trauma

ASJC Scopus subject areas

  • Endocrinology

Cite this

Pittoni, G., Gallioli, G., Zanello, M., Gianotti, L., Boghen, M. F., Colombo, S., Broglio, F., Santoro, C., Davià, G., Papini, M. G., Destefanis, S., Minuto, F., Miola, C., & Ghigo, E. (2002). Activity of GH/IGF-I axis in trauma and septic patients during artificial nutrition: Different behavior patterns? Journal of Endocrinological Investigation, 25(3), 214-223.