Activity of L-carnitine and L-acetylcarnitine on cholinoceptive neocortical neurons of the rat in vivo

L. Janiri, M. Falcone, A. Persico, E. Tempesta

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Carnitine and acetylcarnitine have been demonstrated to be present in the CNS and to be involved in cholinergic mechanisms, even if their exact role in neurotransmission is still unknown. This microiontophoretic study was carried out on single cholinoceptive neurons of the somatosensory cortex in the rat in order to analyze the effects of L- and D-carnitine and L-acetylcarnitine on the spontaneous firing and the neuronal responses to some putative transmitters. L-carnitine and L-acetylcarnitine increased the spontaneous discharge rate, while D-carnitine was found to be ineffective. L-acetylcarnitine clearly potentiated the cholinergic excitatory responses. On the contrary, L-carnitine was found to reduce cholinergic responses in a great percentage of units and to inhibit L-acetylcarnitine-induced excitatory responses. Atropine blocked the increase in firing rate induced by L-carnitine and L-acetylcarnitine, thus suggesting for both of them a muscarinic activity. No interactions were observed between carnitines and GABA and glutamate. These results show that carnitine and acetylcarnitine are stereospecific neuroactive compounds with a cholinomimetic activity. They may play a role in a modulatory system for the cholinoceptive cortical neuron.

Original languageEnglish
Pages (from-to)135-146
Number of pages12
JournalJournal of Neural Transmission
Volume86
Issue number2
DOIs
Publication statusPublished - Jun 1991

Fingerprint

Acetylcarnitine
Carnitine
Neurons
Cholinergic Agents
Somatosensory Cortex
Atropine
Synaptic Transmission
gamma-Aminobutyric Acid
Glutamic Acid

Keywords

  • acetylcarnitine
  • acetylcholine
  • Carnitine
  • cerebral cortex
  • microiontophoresis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Activity of L-carnitine and L-acetylcarnitine on cholinoceptive neocortical neurons of the rat in vivo. / Janiri, L.; Falcone, M.; Persico, A.; Tempesta, E.

In: Journal of Neural Transmission, Vol. 86, No. 2, 06.1991, p. 135-146.

Research output: Contribution to journalArticle

Janiri, L. ; Falcone, M. ; Persico, A. ; Tempesta, E. / Activity of L-carnitine and L-acetylcarnitine on cholinoceptive neocortical neurons of the rat in vivo. In: Journal of Neural Transmission. 1991 ; Vol. 86, No. 2. pp. 135-146.
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