Activity of levofloxacin and ciprofloxacin against urinary pathogens

L. Drago, E. De Vecchi, B. Mombelli, L. Nicola, M. Valli, M. R. Gismondo

Research output: Contribution to journalArticlepeer-review


This study compares the antibacterial activities of levofloxacin and ciprofloxacin against recently isolated urinary tract pathogens, by evaluating their MICs and MBCs in accordance with NCCLS susceptibility tests, time-kill curves and interference with bacterial adhesion to uroepithelial cells. A total of 200 clinical isolates was tested, including the species Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus and Staphylococcus epidermidis. All E. coli isolates were susceptible to levofloxacin and only one was resistant to ciprofloxacin, and there were no differences between β-lactamase-positive and -negative strains. K. pneumoniae strains resistant to ciprofloxacin were also resistant to levofloxacin. Methicillin-resistant S. aureus seemed to be less susceptible than methicillin-susceptible strains to these quinolones. S. epidermidis strains were susceptible to levofloxacin and ciprofloxacin, with the exception of two isolates. Incubation of S. aureus and E. coli with subinhibitory antimicrobial concentrations reduced their capacity to adhere to uroepithelial cells; this was statistically significant at 0.25 × MIC with respect to controls (P

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalJournal of Antimicrobial Chemotherapy
Issue number1
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Microbiology
  • Pharmacology


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