Abstract
We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16% of strains, and among them 19% had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16% had MIC at breakpoint for daptomycin and 11% had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.
| Original language | English |
|---|---|
| Pages (from-to) | 273-275 |
| Number of pages | 3 |
| Journal | Journal of Chemotherapy |
| Volume | 26 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1 2014 |
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Keywords
- Daptomycin
- Increased minimal inhibitory concentration
- Linezolid
- Methicillin-resistant coagulase-negative staphylococci
- Pediatric patients
- Vancomycin
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
- Oncology
- Pharmacology
- Medicine(all)
Cite this
Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients. / Castagnola, Elio; Amoroso, Loredana; Banov, Laura; Faraci, Maura; Loy, Anna; Moscatelli, Andrea; Risso, Francesco; Barabino, Paola; Ciucci, Antonella; Bandettini, Roberto.
In: Journal of Chemotherapy, Vol. 26, No. 5, 01.10.2014, p. 273-275.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients
AU - Castagnola, Elio
AU - Amoroso, Loredana
AU - Banov, Laura
AU - Faraci, Maura
AU - Loy, Anna
AU - Moscatelli, Andrea
AU - Risso, Francesco
AU - Barabino, Paola
AU - Ciucci, Antonella
AU - Bandettini, Roberto
PY - 2014/10/1
Y1 - 2014/10/1
N2 - We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16% of strains, and among them 19% had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16% had MIC at breakpoint for daptomycin and 11% had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.
AB - We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16% of strains, and among them 19% had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16% had MIC at breakpoint for daptomycin and 11% had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.
KW - Daptomycin
KW - Increased minimal inhibitory concentration
KW - Linezolid
KW - Methicillin-resistant coagulase-negative staphylococci
KW - Pediatric patients
KW - Vancomycin
UR - http://www.scopus.com/inward/record.url?scp=84918811957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84918811957&partnerID=8YFLogxK
U2 - 10.1179/1973947813Y.0000000134
DO - 10.1179/1973947813Y.0000000134
M3 - Article
VL - 26
SP - 273
EP - 275
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
SN - 1120-009X
IS - 5
ER -