Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients

Elio Castagnola, Loredana Amoroso, Laura Banov, Maura Faraci, Anna Loy, Andrea Moscatelli, Francesco Risso, Paola Barabino, Antonella Ciucci, Roberto Bandettini

Research output: Contribution to journalArticle

Abstract

We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16% of strains, and among them 19% had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16% had MIC at breakpoint for daptomycin and 11% had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.

Original languageEnglish
Pages (from-to)273-275
Number of pages3
JournalJournal of Chemotherapy
Volume26
Issue number5
DOIs
Publication statusPublished - Oct 1 2014

Keywords

  • Daptomycin
  • Increased minimal inhibitory concentration
  • Linezolid
  • Methicillin-resistant coagulase-negative staphylococci
  • Pediatric patients
  • Vancomycin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Oncology
  • Pharmacology
  • Medicine(all)

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