Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients

Elio Castagnola; Loredana Amoroso; Laura Banov; Maura Faraci; Anna Loy; Andrea Moscatelli; Francesco Risso; Paola Barabino; Antonella Ciucci; Roberto Bandettini

doi:10.1179/1973947813Y.0000000134

Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients

Elio Castagnola, Loredana Amoroso, Laura Banov, Maura Faraci, Anna Loy, Andrea Moscatelli, Francesco Risso, Paola Barabino, Antonella Ciucci, Roberto Bandettini

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16% of strains, and among them 19% had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16% had MIC at breakpoint for daptomycin and 11% had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.

Original language	English
Pages (from-to)	273-275
Number of pages	3
Journal	Journal of Chemotherapy
Volume	26
Issue number	5
DOIs	https://doi.org/10.1179/1973947813Y.0000000134
Publication status	Published - Oct 1 2014

Keywords

Daptomycin
Increased minimal inhibitory concentration
Linezolid
Methicillin-resistant coagulase-negative staphylococci
Pediatric patients
Vancomycin

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Oncology
Pharmacology
Medicine(all)

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Castagnola, E., Amoroso, L., Banov, L., Faraci, M., Loy, A., Moscatelli, A., Risso, F., Barabino, P., Ciucci, A., & Bandettini, R. (2014). Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients. Journal of Chemotherapy, 26(5), 273-275. https://doi.org/10.1179/1973947813Y.0000000134

Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients. / Castagnola, Elio; Amoroso, Loredana; Banov, Laura; Faraci, Maura; Loy, Anna; Moscatelli, Andrea; Risso, Francesco; Barabino, Paola; Ciucci, Antonella; Bandettini, Roberto.

In: Journal of Chemotherapy, Vol. 26, No. 5, 01.10.2014, p. 273-275.

Research output: Contribution to journal › Article › peer-review

Castagnola, E, Amoroso, L, Banov, L, Faraci, M, Loy, A, Moscatelli, A, Risso, F, Barabino, P, Ciucci, A & Bandettini, R 2014, 'Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients', Journal of Chemotherapy, vol. 26, no. 5, pp. 273-275. https://doi.org/10.1179/1973947813Y.0000000134

Castagnola, Elio ; Amoroso, Loredana ; Banov, Laura ; Faraci, Maura ; Loy, Anna ; Moscatelli, Andrea ; Risso, Francesco ; Barabino, Paola ; Ciucci, Antonella ; Bandettini, Roberto. / Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients. In: Journal of Chemotherapy. 2014 ; Vol. 26, No. 5. pp. 273-275.

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abstract = "We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16% of strains, and among them 19% had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16% had MIC at breakpoint for daptomycin and 11% had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.",

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AU - Faraci, Maura

AU - Loy, Anna

AU - Moscatelli, Andrea

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Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients

Abstract

Keywords

ASJC Scopus subject areas

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