Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients

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3 Citations (Scopus)

Abstract

We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16% of strains, and among them 19% had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16% had MIC at breakpoint for daptomycin and 11% had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.

Original languageEnglish
Pages (from-to)273-275
Number of pages3
JournalJournal of Chemotherapy
Volume26
Issue number5
DOIs
Publication statusPublished - Oct 1 2014

Fingerprint

Linezolid
Daptomycin
Methicillin Resistance
Coagulase
Vancomycin
Staphylococcus
Pediatrics
Treatment Failure
Pharmaceutical Preparations
Blood Culture

Keywords

  • Daptomycin
  • Increased minimal inhibitory concentration
  • Linezolid
  • Methicillin-resistant coagulase-negative staphylococci
  • Pediatric patients
  • Vancomycin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Oncology
  • Pharmacology
  • Medicine(all)

Cite this

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title = "Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients",
abstract = "We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16{\%} of strains, and among them 19{\%} had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16{\%} had MIC at breakpoint for daptomycin and 11{\%} had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.",
keywords = "Daptomycin, Increased minimal inhibitory concentration, Linezolid, Methicillin-resistant coagulase-negative staphylococci, Pediatric patients, Vancomycin",
author = "Elio Castagnola and Loredana Amoroso and Laura Banov and Maura Faraci and Anna Loy and Andrea Moscatelli and Francesco Risso and Paola Barabino and Antonella Ciucci and Roberto Bandettini",
year = "2014",
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T1 - Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients

AU - Castagnola, Elio

AU - Amoroso, Loredana

AU - Banov, Laura

AU - Faraci, Maura

AU - Loy, Anna

AU - Moscatelli, Andrea

AU - Risso, Francesco

AU - Barabino, Paola

AU - Ciucci, Antonella

AU - Bandettini, Roberto

PY - 2014/10/1

Y1 - 2014/10/1

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AB - We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16% of strains, and among them 19% had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16% had MIC at breakpoint for daptomycin and 11% had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.

KW - Daptomycin

KW - Increased minimal inhibitory concentration

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KW - Methicillin-resistant coagulase-negative staphylococci

KW - Pediatric patients

KW - Vancomycin

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