Abstract
We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16% of strains, and among them 19% had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16% had MIC at breakpoint for daptomycin and 11% had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.
| Original language | English |
|---|---|
| Pages (from-to) | 273-275 |
| Number of pages | 3 |
| Journal | Journal of Chemotherapy |
| Volume | 26 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1 2014 |
Keywords
- Daptomycin
- Increased minimal inhibitory concentration
- Linezolid
- Methicillin-resistant coagulase-negative staphylococci
- Pediatric patients
- Vancomycin
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
- Oncology
- Pharmacology
- Medicine(all)
Fingerprint Dive into the research topics of 'Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients'. Together they form a unique fingerprint.
Cite this
Castagnola, E., Amoroso, L., Banov, L., Faraci, M., Loy, A., Moscatelli, A., Risso, F., Barabino, P., Ciucci, A., & Bandettini, R. (2014). Activity of linezolid and daptomycin against Methicillin-Resistant Coagulase-Negative staphylococci with increased MIC for vancomycin isolated from blood cultures in pediatric patients. Journal of Chemotherapy, 26(5), 273-275. https://doi.org/10.1179/1973947813Y.0000000134