Abstract
We evaluated minimal inhibitory concentration (MIC) for vancomycin, daptomycin, and linezolid in methicillin-resistant coagulase-negative staphylococci (MR-CoNS). Minimal inhibitory concentration of 2-4 mg/l for vancomycin was observed in 16% of strains, and among them 19% had MIC at breakpoint for daptomycin or linezolid. Among strains completely susceptible to vancomycin, 16% had MIC at breakpoint for daptomycin and 11% had for linezolid. This large proportion of pathogens with MIC around the breakpoint suggests a possible risk of treatment failure with these drugs. This phenomenon is worth further and constant monitoring.
Original language | English |
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Pages (from-to) | 273-275 |
Number of pages | 3 |
Journal | Journal of Chemotherapy |
Volume | 26 |
Issue number | 5 |
DOIs | |
Publication status | Published - Oct 1 2014 |
Keywords
- Daptomycin
- Increased minimal inhibitory concentration
- Linezolid
- Methicillin-resistant coagulase-negative staphylococci
- Pediatric patients
- Vancomycin
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
- Oncology
- Pharmacology
- Medicine(all)