Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of mycobacterium avium complex

C. Piersimoni, E. Tortoli, M. T. Mascellino, C. Passerini Tosi, G. Sbaraglia, F. Mandler, F. Bistoni, S. Bornigia, G. De Sio, A. Goglio, E. Iona, M. B. Pasticci, M. T. Simonetti

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The activity of seven antimicrobial agents (and five two-drug combinations and five three-drug combinations) was investigated against 37 clinical isolates of Mycobacterium avium recovered from blood cultures of AIDS patients. The susceptibility tests were performed in Middlebrook 7H12 broth using a radiometric method. MICs of amikacin, ciprofloxacin, clarithromycin, clofazimine, ethambutol, rifabutin and sparfloxacin were determined. Five antimicrobial agents were tested in combination with clarithromycin and also with clarithromycin plus amikacin to look for possible synergic activity. Synergic activity in combination with clarithromycin and with clarithromycin plus amikacin, was detected for rifabutin (54% and 51% of isolates, respectively), clofazimine (38% and 35%), ethambutol (16% and 32%), ciprofloxacin (8% and 14%) and sparfloxacin (3% and 8%). No antagonism was observed. We conclude that clarithromycin is an essential component in the chemotherapy of M. avium complex disease.

Original languageEnglish
Pages (from-to)497-502
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume36
Issue number3
DOIs
Publication statusPublished - Sep 1995

Fingerprint

Antimicrobial agents
Mycobacterium avium Complex
Clarithromycin
Anti-Infective Agents
Acquired Immunodeficiency Syndrome
Chemotherapy
Amikacin
Clofazimine
Rifabutin
Ethambutol
Drugs
Blood
Drug Combinations
Ciprofloxacin
Antagonism
Essential Component
Susceptibility
Mycobacterium avium
Drug Therapy

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)
  • Pharmacology
  • Microbiology

Cite this

Piersimoni, C., Tortoli, E., Mascellino, M. T., Tosi, C. P., Sbaraglia, G., Mandler, F., ... Simonetti, M. T. (1995). Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of mycobacterium avium complex. Journal of Antimicrobial Chemotherapy, 36(3), 497-502. https://doi.org/10.1093/jac/36.3.497

Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of mycobacterium avium complex. / Piersimoni, C.; Tortoli, E.; Mascellino, M. T.; Tosi, C. Passerini; Sbaraglia, G.; Mandler, F.; Bistoni, F.; Bornigia, S.; Sio, G. De; Goglio, A.; Iona, E.; Pasticci, M. B.; Simonetti, M. T.

In: Journal of Antimicrobial Chemotherapy, Vol. 36, No. 3, 09.1995, p. 497-502.

Research output: Contribution to journalArticle

Piersimoni, C, Tortoli, E, Mascellino, MT, Tosi, CP, Sbaraglia, G, Mandler, F, Bistoni, F, Bornigia, S, Sio, GD, Goglio, A, Iona, E, Pasticci, MB & Simonetti, MT 1995, 'Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of mycobacterium avium complex', Journal of Antimicrobial Chemotherapy, vol. 36, no. 3, pp. 497-502. https://doi.org/10.1093/jac/36.3.497
Piersimoni, C. ; Tortoli, E. ; Mascellino, M. T. ; Tosi, C. Passerini ; Sbaraglia, G. ; Mandler, F. ; Bistoni, F. ; Bornigia, S. ; Sio, G. De ; Goglio, A. ; Iona, E. ; Pasticci, M. B. ; Simonetti, M. T. / Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of mycobacterium avium complex. In: Journal of Antimicrobial Chemotherapy. 1995 ; Vol. 36, No. 3. pp. 497-502.
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