Activity of single agent vinorelbine in pretreated non-Hodgkin's lymphoma

M. Balzarotti, A. Santoro, C. Tondini, M. Fornier, G. Bonadonna

Research output: Contribution to journalArticle

Abstract

Background: To assess the activity of single agent vinorelbine in pretreated non Hodgkin's lymphoma. Patients and methods: Twenty-three pretreated patients with non-Hodgkin's lymphoma (14 intermediate-high grade, nine low-grade) were treated with vinorelbine 30 mg/m2/week for six months or up to four doses after achieving CR. Results: Among 13 evaluable patients with intermediate-high grade lymphoma, three obtained CR and three PR, for an overall response rate of 46% (95%: 19%-75%). Median duration of response was six months. Otherwise, vinorelbine did not show any significant activity in chemotherapy-refractory low-grade non-Hodgkin's lymphoma. Toxicity was acceptable, and the drug was well-tolerated even in elderly patients. Conclusions: The good activity and tolerability of vinorelbine in relapsed intermediate-high grade lymphoma suggest its inclusion in first-line regimens, especially in elderly patients.

Original languageEnglish
Pages (from-to)970-972
Number of pages3
JournalAnnals of Oncology
Volume7
Issue number9
Publication statusPublished - Nov 1996

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Non-Hodgkin's Lymphoma
vinorelbine
Drug Therapy
Pharmaceutical Preparations

Keywords

  • non-Hodgkin's lymphoma
  • salvage therapy
  • vinorelbine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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Activity of single agent vinorelbine in pretreated non-Hodgkin's lymphoma. / Balzarotti, M.; Santoro, A.; Tondini, C.; Fornier, M.; Bonadonna, G.

In: Annals of Oncology, Vol. 7, No. 9, 11.1996, p. 970-972.

Research output: Contribution to journalArticle

Balzarotti, M, Santoro, A, Tondini, C, Fornier, M & Bonadonna, G 1996, 'Activity of single agent vinorelbine in pretreated non-Hodgkin's lymphoma', Annals of Oncology, vol. 7, no. 9, pp. 970-972.
Balzarotti, M. ; Santoro, A. ; Tondini, C. ; Fornier, M. ; Bonadonna, G. / Activity of single agent vinorelbine in pretreated non-Hodgkin's lymphoma. In: Annals of Oncology. 1996 ; Vol. 7, No. 9. pp. 970-972.
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