Activity-rest stimulation of latissimus dorsi for cardiomyoplasty

1- Year results in sheep

Giorgio Arpesella, Ugo Carraro, Piero M. Mikus, Franco Dozza, Pierloca Lombardi, Giuseppe Marinelli, Sandra Zampieri, Abdul H. El Messlemani, Katia Rossini, Angelo Pierangeli

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background. In dynamic cardiomyoplasty electrostimulation achieves full transformation of the latissimus dorsi (LD); therefore, its slowness limits the systolic support. Daily activity-rest Could maintain partial transformation of the LD. Methods. Sheep LD were burst-stimulated either 10 or 24 hours/day. Before and 2, 4, 6, and 12 months after stimulation, LD power output, fatigue resistance, and tetanic fusion frequency were assessed. Latissimus dorsi were biopsied at 6 months, and sheep sacrificed at 12 months. Results. After 1 year of 10 hours/day stimulation LD was substantially conserved and contained large amounts of fast type myosin. From 2 months to 1 year of stimulation the power per muscle of the daily rested LD was greater than that of the left ventricle, being three to four times higher than in the 24-hour/day stimulation. Conclusions. If extended to humans, these results could be the rationale for the need of a cardiomyostimulator, whose discontinuous activity could offer to patients the long-standing advantage of a faster and powerful muscle contraction.

Original languageEnglish
Pages (from-to)1983-1990
Number of pages8
JournalAnnals of Thoracic Surgery
Volume66
Issue number6
DOIs
Publication statusPublished - 1998

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Cardiomyoplasty
Superficial Back Muscles
Sheep
Myosins
Muscle Contraction
Heart Ventricles
Fatigue
Muscles

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Arpesella, G., Carraro, U., Mikus, P. M., Dozza, F., Lombardi, P., Marinelli, G., ... Pierangeli, A. (1998). Activity-rest stimulation of latissimus dorsi for cardiomyoplasty: 1- Year results in sheep. Annals of Thoracic Surgery, 66(6), 1983-1990. https://doi.org/10.1016/S0003-4975(98)00906-0

Activity-rest stimulation of latissimus dorsi for cardiomyoplasty : 1- Year results in sheep. / Arpesella, Giorgio; Carraro, Ugo; Mikus, Piero M.; Dozza, Franco; Lombardi, Pierloca; Marinelli, Giuseppe; Zampieri, Sandra; El Messlemani, Abdul H.; Rossini, Katia; Pierangeli, Angelo.

In: Annals of Thoracic Surgery, Vol. 66, No. 6, 1998, p. 1983-1990.

Research output: Contribution to journalArticle

Arpesella, G, Carraro, U, Mikus, PM, Dozza, F, Lombardi, P, Marinelli, G, Zampieri, S, El Messlemani, AH, Rossini, K & Pierangeli, A 1998, 'Activity-rest stimulation of latissimus dorsi for cardiomyoplasty: 1- Year results in sheep', Annals of Thoracic Surgery, vol. 66, no. 6, pp. 1983-1990. https://doi.org/10.1016/S0003-4975(98)00906-0
Arpesella, Giorgio ; Carraro, Ugo ; Mikus, Piero M. ; Dozza, Franco ; Lombardi, Pierloca ; Marinelli, Giuseppe ; Zampieri, Sandra ; El Messlemani, Abdul H. ; Rossini, Katia ; Pierangeli, Angelo. / Activity-rest stimulation of latissimus dorsi for cardiomyoplasty : 1- Year results in sheep. In: Annals of Thoracic Surgery. 1998 ; Vol. 66, No. 6. pp. 1983-1990.
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AB - Background. In dynamic cardiomyoplasty electrostimulation achieves full transformation of the latissimus dorsi (LD); therefore, its slowness limits the systolic support. Daily activity-rest Could maintain partial transformation of the LD. Methods. Sheep LD were burst-stimulated either 10 or 24 hours/day. Before and 2, 4, 6, and 12 months after stimulation, LD power output, fatigue resistance, and tetanic fusion frequency were assessed. Latissimus dorsi were biopsied at 6 months, and sheep sacrificed at 12 months. Results. After 1 year of 10 hours/day stimulation LD was substantially conserved and contained large amounts of fast type myosin. From 2 months to 1 year of stimulation the power per muscle of the daily rested LD was greater than that of the left ventricle, being three to four times higher than in the 24-hour/day stimulation. Conclusions. If extended to humans, these results could be the rationale for the need of a cardiomyostimulator, whose discontinuous activity could offer to patients the long-standing advantage of a faster and powerful muscle contraction.

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