TY - JOUR
T1 - Acute administration of individual optimal dose of physostigmine fails to improve mnesic performances in alzheimers presenile dementia
AU - Caltagirone, C.
AU - Albanese, A.
AU - Gainotti, G.
AU - Masullo, C.
PY - 1983
Y1 - 1983
N2 - Eight patients affected by Alzheimer's Presenile Dementia (AD) received acute administration of physostigmine individual optimal dose per os (n = 4) or subcutaneously (n = 4). The individual physostigmine dose was assessed by means of serum cholinesterase activity monitoring. The possible beneficial effects after treatment were evaluated by using two memory tests: Reys' 15 words and Digit Span from Wechsler memory scale. Although a slight behavioral activation was noted in all patients after treatment, the comparison between mean scores obtained by AD patients in mnesic tests before and after the acute physostigmine administration, with either therapeutic modality, failed to reach the level of statistical significance. Some implications of these disappointing results are briefly discussed.
AB - Eight patients affected by Alzheimer's Presenile Dementia (AD) received acute administration of physostigmine individual optimal dose per os (n = 4) or subcutaneously (n = 4). The individual physostigmine dose was assessed by means of serum cholinesterase activity monitoring. The possible beneficial effects after treatment were evaluated by using two memory tests: Reys' 15 words and Digit Span from Wechsler memory scale. Although a slight behavioral activation was noted in all patients after treatment, the comparison between mean scores obtained by AD patients in mnesic tests before and after the acute physostigmine administration, with either therapeutic modality, failed to reach the level of statistical significance. Some implications of these disappointing results are briefly discussed.
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U2 - 10.3109/00207458308985888
DO - 10.3109/00207458308985888
M3 - Article
C2 - 6840979
AN - SCOPUS:0020682064
VL - 18
SP - 143
EP - 147
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
SN - 0020-7454
IS - 1-2
ER -