Acute and chronic ethanol administration on specific 3H-GABA binding in different rat brain areas

A. Reggiani, M. L. Barbaccia, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

Acute ethanol treatment produces a significant decrease of specific 3H-GABA binding in cerebellum while no changes were detectable in other brain areas. Scatchard analysis shows a decrease in receptor affinity but not in the number of GABA binding sites. On the other hand, chronic administration of ethanol selectively increases specific 3H-GABA binding in the striatum. Kinetic analysis of these data shows that ethanol chronic administration produces a significant increase in the number of GABA binding sites. These data may be useful for the understanding of clinical pictures following acute and chronic ethanol intoxication.

Original languageEnglish
Pages (from-to)261-264
Number of pages4
JournalPsychopharmacology
Volume67
Issue number3
DOIs
Publication statusPublished - Mar 1980

Keywords

  • Cerebellum
  • Ethanol
  • Specific H-GABA binding
  • Striatum

ASJC Scopus subject areas

  • Pharmacology

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