Abstract
Acute ethanol treatment produces a significant decrease of specific 3H-GABA binding in cerebellum while no changes were detectable in other brain areas. Scatchard analysis shows a decrease in receptor affinity but not in the number of GABA binding sites. On the other hand, chronic administration of ethanol selectively increases specific 3H-GABA binding in the striatum. Kinetic analysis of these data shows that ethanol chronic administration produces a significant increase in the number of GABA binding sites. These data may be useful for the understanding of clinical pictures following acute and chronic ethanol intoxication.
Original language | English |
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Pages (from-to) | 261-264 |
Number of pages | 4 |
Journal | Psychopharmacology |
Volume | 67 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 1980 |
Keywords
- Cerebellum
- Ethanol
- Specific H-GABA binding
- Striatum
ASJC Scopus subject areas
- Pharmacology