Abstract
Acute ethanol treatment produces a significant decrease of specific 3H-GABA binding in cerebellum while no changes were detectable in other brain areas. Scatchard analysis shows a decrease in receptor affinity but not in the number of GABA binding sites. On the other hand, chronic administration of ethanol selectively increases specific 3H-GABA binding in the striatum. Kinetic analysis of these data shows that ethanol chronic administration produces a significant increase in the number of GABA binding sites. These data may be useful for the understanding of clinical pictures following acute and chronic ethanol intoxication.
| Original language | English |
|---|---|
| Pages (from-to) | 261-264 |
| Number of pages | 4 |
| Journal | Psychopharmacology |
| Volume | 67 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1980 |
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Keywords
- Cerebellum
- Ethanol
- Specific H-GABA binding
- Striatum
ASJC Scopus subject areas
- Pharmacology
Cite this
Acute and chronic ethanol administration on specific 3H-GABA binding in different rat brain areas. / Reggiani, A.; Barbaccia, M. L.; Spano, P. F.; Trabucchi, M.
In: Psychopharmacology, Vol. 67, No. 3, 03.1980, p. 261-264.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute and chronic ethanol administration on specific 3H-GABA binding in different rat brain areas
AU - Reggiani, A.
AU - Barbaccia, M. L.
AU - Spano, P. F.
AU - Trabucchi, M.
PY - 1980/3
Y1 - 1980/3
N2 - Acute ethanol treatment produces a significant decrease of specific 3H-GABA binding in cerebellum while no changes were detectable in other brain areas. Scatchard analysis shows a decrease in receptor affinity but not in the number of GABA binding sites. On the other hand, chronic administration of ethanol selectively increases specific 3H-GABA binding in the striatum. Kinetic analysis of these data shows that ethanol chronic administration produces a significant increase in the number of GABA binding sites. These data may be useful for the understanding of clinical pictures following acute and chronic ethanol intoxication.
AB - Acute ethanol treatment produces a significant decrease of specific 3H-GABA binding in cerebellum while no changes were detectable in other brain areas. Scatchard analysis shows a decrease in receptor affinity but not in the number of GABA binding sites. On the other hand, chronic administration of ethanol selectively increases specific 3H-GABA binding in the striatum. Kinetic analysis of these data shows that ethanol chronic administration produces a significant increase in the number of GABA binding sites. These data may be useful for the understanding of clinical pictures following acute and chronic ethanol intoxication.
KW - Cerebellum
KW - Ethanol
KW - Specific H-GABA binding
KW - Striatum
UR - http://www.scopus.com/inward/record.url?scp=0018889594&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018889594&partnerID=8YFLogxK
U2 - 10.1007/BF00431267
DO - 10.1007/BF00431267
M3 - Article
C2 - 6770406
AN - SCOPUS:0018889594
VL - 67
SP - 261
EP - 264
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 3
ER -